Search: onr:"swepub:oai:DiVA.org:umu-42943" >
The solution NMR st...
The solution NMR structure of a blue-green algae hepatotoxin, microcystin-RR--a comparison with the structure of microcystin-LR.
- Article/chapterEnglish1998
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:DiVA.org:umu-42943
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42943URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
The microcystin-RR structures are compared with the structures of microcystin-LR in solution as well as in the crystal structure of the complex with protein phosphatase. The gross structures of the two peptides are similar, but with a more accentuated and compact saddle structure for microcystin-RR. The structural differences affect the hydrogen-bond pattern in the peptides and the location of the side chain of N-methyldehydroalanine, both of which are important for the ability of the peptide to form a tight complex with protein phosphatase. These structural differences may contribute to the observed differences in toxicity of microcystin-RR and microcystin-LR.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Edlund, U
(author)
-
Larsson, Göran
(author)
-
Sethson, I
(author)
Related titles
-
In:European Journal of Biochemistry258:2, s. 301-120014-29561432-1033
Internet link
Find in a library
To the university's database