WFRF:(Novikova J.)
Sökning: WFRF:(Novikova J.) > Neuroprotective and...
- 37 av 45
- Föregående post
- Nästa post
- Till träfflistan
- Novikova, Liudmila NUmeå universitet,Anatomi (författare)
Neuroprotective and growth-promoting effects of bone marrow stromal cells after cervical spinal cord injury in adult rats
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
- Elsevier BV,2011
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:umu-44220
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-44220URI
- https://doi.org/10.3109/14653249.2011.574116DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Background aims. Bone marrow stromal cells (BMSC) have been shown to provide neuroprotection after transplantation into the injured central nervous system. The present study investigated whether adult rat BMSC differentiated along a Schwann cell lineage could increase production of trophic factors and support neuronal survival and axonal regeneration after transplantation into the injured spinal cord. Methods. After cervical C4 hemi-section, 5-bromo-2-deoxyuridine (BrdU)/green fluorescent protein (GFP)-labeled BMSC were injected into the lateral funiculus at 1 mm rostral and caudal to the lesion site. Spinal cords were analyzed 2-13 weeks after transplantation. Results and Conclusions. Treatment of native BMSC with Schwann cell-differentiating factors significantly increased production of brain-derived neurotrophic factor in vitro. Transplanted undifferentiated and differentiated BMSC remained at the injection sites, and in the trauma zone were often associated with neurofilament-positive fibers and increased levels of vascular endothelial growth factor. BMSC promoted extensive in-growth of serotonin-positive raphaespinal axons and calcitonin gene-related peptide (CGRP)-positive dorsal root sensory axons into the trauma zone, and significantly attenuated astroglial and microglial cell reactions, but induced aberrant sprouting of CGRP-immunoreactive axons in Rexed's lamina III. Differentiated BMSC provided neuroprotection for axotomized rubrospinal neurons and increased the density of rubrospinal axons in the dorsolateral funiculus rostral to the injury site. The present results suggest that BMSC induced along the Schwann cell lineage increase expression of trophic factors and have neuroprotective and growth-promoting effects after spinal cord injury.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- bone marrow
- mesenchymal stromal cells
- red nucleus
- retrograde degeneration
- spinal cord trauma
- transplantation
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Brohlin, MariaUmeå universitet,Anatomi(Swepub:umu)mabr0001 (författare)
- Kingham, Paul JUmeå universitet,Anatomi(Swepub:umu)paki0006 (författare)
- Novikov, Lev NUmeå universitet,Anatomi(Swepub:umu)leno0001 (författare)
- Wiberg, MikaelUmeå universitet,Anatomi,Handkirurgi(Swepub:umu)miwi0004 (författare)
- Umeå universitetAnatomi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Cytotherapy: Elsevier BV13:7, s. 873-8871465-32491477-2566
Internetlänk
- 37 av 45
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Novikova, Liudmi ...
- Brohlin, Maria
- Kingham, Paul J
- Novikov, Lev N
- Wiberg, Mikael
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Neurovetenskaper
- Artiklar i publikationen
- Cytotherapy
- Av lärosätet
- Umeå universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
