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Only amyloidogenic inermediates of transthyretin induce apoptosis
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- Andersson, Karin (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Olofsson, Anders, 1970- (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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Holm Nielsen, Ellen (author)
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Svehag, SvenErik (author)
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- Lundgren, Erik (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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(creator_code:org_t)
- Carolina Academic Press, 2002
- 2002
- English.
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In: Biochemical and Biophysical Research Communications - BBRC. - : Carolina Academic Press. - 0006-291X .- 1090-2104. ; 294:2, s. 309-314
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In diseases like Alzheimer's disease and familial amyloidotic polyneuropathy (FAP) amyloid deposits co-localize with areas of neurodegeneration. FAP is associated with mutations of the plasma protein transthyretin (TTR). We can here show an apoptotic effect of amyloidogenic mutants of TTR on a human neuroblastoma cell line. Toxicity could be blocked by catalase indicating a free oxygen radical dependent mechanism. The toxic effect was dependent on the state of aggregation and unexpectedly mature fibrils from FAP-patients who failed to exert an apoptotic response. Morphological studies revealed a correlation between toxicity and the presence of immature amyloid. Thus, we can show that toxicity is associated with early stages of fibril formation and propose that mature full-length fibrils represent an inert end stage, which might serve as a rescue mechanism.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Amyloid
- Transthyretin
- Cytotoxicity
- Apoptosis
- Free radicals
Publication and Content Type
- ref (subject category)
- art (subject category)
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