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Search: WFRF:(Wallensteen M) > (2000-2004) > Insulin-like growth...

  • Zachrisson, IKarolinska Institutet (author)

Insulin-like growth factor binding protein-1 as glucose regulator in adolescent boys with type 1 diabetes.

  • Article/chapterEnglish2000

Publisher, publication year, extent ...

  • 2000
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-45418
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45418URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1932167URI
  • https://doi.org/10.1080/713794574DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The aim of the present study was to investigate whether the diurnal variability of B-Glucose is dependent on GH, IGF-I and IGFBP-1 levels, apart from insulin, and if there is any difference between Tanner stages 3 and 5. Five boys in Tanner stage 3 and 6 boys in stage 5 with type 1 diabetes were included. Blood was continuously collected from a cubital vein for 24 h. S-Insulin, S-GH, S-IGF-I and S-IGFBP-1 were analysed. B-Glucose was analysed hourly at bedside. One week before and 1 wk after the 24-h study period the participants performed self-monitoring of blood glucose (SMBG) during normal physiologic conditions. In the 24-h profile of B-Glucose, insulin, IGFBP-1 and GH, we found a significant positive correlation between B-Glucose and log IGFBP-1 (r = 0.5, p = 0.005) and an inverse correlation to insulin (r = -0.5, p = 0.004) but no correlation to logGH (r = -0.04, p = 0.831). In multiple regression analysis, B-Glucose was still significantly correlated to log IGFBP-1, when adjusting for insulin and GH, in Tanner stage 5. We found a difference between Tanner stages 3 and 5 in the variability of B-Glucose over a longer period during normal daily activity (p = 0.02), but not over the 24-h study period. CONCLUSION: We have demonstrated in type 1 diabetes adolescent boys a relationship between simultaneously measured blood-glucose and IGFBP-1 levels independent of the insulin and GH levels, suggesting that the free fraction of IGF-I influences the glucose metabolism.

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  • Dahlquist, Gisela,1944-Umeå universitet,Pediatrik(Swepub:umu)gida0001 (author)
  • Wallensteen, MAstrid Lindgren Children’s Hospital, Karolinska Hospital and Institute, Stockholm, Sweden (author)
  • Brismar, KKarolinska Institutet (author)
  • Karolinska InstitutetPediatrik (creator_code:org_t)

Related titles

  • In:Acta Paediatrica89:9, s. 1044-90803-52531651-2227

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Zachrisson, I
Dahlquist, Gisel ...
Wallensteen, M
Brismar, K
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Pediatrics
Articles in the publication
Acta Paediatrica
By the university
Umeå University
Karolinska Institutet

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