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  • Andersson, UlrikaUmeå universitet,Onkologi (author)

Rapid induction of long-lasting drug efflux activity in brain vascular endothelial cells but not malignant glioma following irradiation

  • Article/chapterEnglish2002

Publisher, publication year, extent ...

  • 2002
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-4545
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-4545URI
  • https://doi.org/10.1385/MO:19:1:1DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The influence of radiotherapy on malignant glioma multidrug resistance to chemotherapy was evaluated because patients with glioma often are treated with a combination of radiotherapy and chemotherapy. Multidrug resistance gene (MDR1, mdr1a, and mdr1b) transcripts were found in human and rat glioma cell lines. P-Glycoprotein (Pgp) was immunohistochemically detected in glioma cell lines and in the rat brain vascular endothelial cell line (RBE4). A multidrug resistance pump efflux activity assay demonstrated increased calcein efflux of RBE4 endothelial cells, but not glioma cells, 2 h after irradiation and still increased 14 d after irradiation. The increased efflux was equally inhibited by verapamil with or without irradiation. In the rat intracranial glioma model (BT4C), Pgp was demonstrated in capillary endothelial cells of the tumor tissue and surrounding normal brain, but not in tumor cells. The expression of gene transcripts or Pgp was not affected by irradiation. The results indicate that long-lasting verapamil-resistant drug efflux mechanisms are activated in brain endothelial cells after irradiation. The results might explain the poor efficacy of chemotherapy following radiotherapy and contribute to consideration of new treatment strategies in the management of malignant glioma.

Subject headings and genre

  • Glioma
  • P-glycoprotein
  • drug resistance
  • blood-brain barrier
  • irradiation

Added entries (persons, corporate bodies, meetings, titles ...)

  • Grankvist, KjellUmeå universitet,Klinisk kemi(Swepub:umu)kjgr0002 (author)
  • Bergenheim, A. TommyUmeå universitet,Neurokirurgi(Swepub:umu)tobe0004 (author)
  • Behnam-Motlagh, ParvizUmeå universitet,Onkologi(Swepub:umu)pabe0001 (author)
  • Hedman, HåkanUmeå universitet,Onkologi(Swepub:umu)hahe0001 (author)
  • Henriksson, RogerUmeå universitet,Onkologi(Swepub:umu)rohe0003 (author)
  • Umeå universitetOnkologi (creator_code:org_t)

Related titles

  • In:Medical Oncology19:1, s. 1-91357-05601559-131X

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