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Evolution and class...
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Makarova, Kira S
(author)
Evolution and classification of the CRISPR-Cas systems
- Article/chapterEnglish2011
Publisher, publication year, extent ...
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2011-05-09
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Nature Publishing Group,2011
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Numbers
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LIBRIS-ID:oai:DiVA.org:umu-45507
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-45507URI
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https://doi.org/10.1038/nrmicro2577DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) modules are adaptive immunity systems that are present in many archaea and bacteria. These defence systems are encoded by operons that have an extraordinarily diverse architecture and a high rate of evolution for both the cas genes and the unique spacer content. Here, we provide an updated analysis of the evolutionary relationships between CRISPR-Cas systems and Cas proteins. Three major types of CRISPR-Cas system are delineated, with a further division into several subtypes and a few chimeric variants. Given the complexity of the genomic architectures and the extremely dynamic evolution of the CRISPR-Cas systems, a unified classification of these systems should be based on multiple criteria. Accordingly, we propose a 'polythetic' classification that integrates the phylogenies of the most common cas genes, the sequence and organization of the CRISPR repeats and the architecture of the CRISPR-cas loci.
Added entries (persons, corporate bodies, meetings, titles ...)
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Haft, Daniel H
(author)
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Barrangou, Rodolphe
(author)
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Brouns, Stan J J
(author)
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Charpentier, EmmanuelleUmeå universitet,Umeå Centre for Microbial Research (UCMR),Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Charpentier(Swepub:umu)emch0006
(author)
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Horvath, Philippe
(author)
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Moineau, Sylvain
(author)
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Mojica, Francisco J M
(author)
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Wolf, Yuri I
(author)
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Yakunin, Alexander F
(author)
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van der Oost, John
(author)
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Koonin, Eugene V
(author)
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Umeå universitetUmeå Centre for Microbial Research (UCMR)
(creator_code:org_t)
Related titles
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In:Nature Reviews Microbiology: Nature Publishing Group9:6, s. 467-4771740-15261740-1534
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Makarova, Kira S
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Haft, Daniel H
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Barrangou, Rodol ...
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Brouns, Stan J J
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Charpentier, Emm ...
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Horvath, Philipp ...
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Moineau, Sylvain
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Wolf, Yuri I
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Koonin, Eugene V
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Umeå University