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Comprehensive analy...
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Kharchenko, Peter VCenter for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Children’s Hospital Informatics Program, Boston, Massachusetts 02115, USA
(författare)
Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2010-12-22
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Springer Science and Business Media LLC,2011
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-46219
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46219URI
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https://doi.org/10.1038/nature09725DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns. Integrative analysis with other data (non-histone chromatin proteins, DNase I hypersensitivity, GRO-Seq reads produced by engaged polymerase, short/long RNA products) reveals discrete characteristics of chromosomes, genes, regulatory elements and other functional domains. We find that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions and genomic contexts. We also demonstrate a diversity of signatures among Polycomb targets that include a subset with paused polymerase. This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Alekseyenko, Artyom ADivision of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
(författare)
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Schwartz, Yuri BUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA(Swepub:umu)yusc0002
(författare)
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Minoda, AkiDepartment of Molecular and Cell Biology, University of California at Berkeley, and Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California 94720, USA
(författare)
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Riddle, Nicole CDepartment of Biology, Washington University in St Louis, St Louis, Missouri 63130, USA
(författare)
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Ernst, JasonMIT Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts 02139, USA,Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
(författare)
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Sabo, Peter JDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
(författare)
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Larschan, EricaDivision of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA and Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02906, USA
(författare)
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Gorchakov, Andrey ADivision of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
(författare)
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Gu, TingtingDepartment of Biology, Washington University in St Louis, St Louis, Missouri 63130, USA
(författare)
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Linder-Basso, DanielaDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
(författare)
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Plachetka, AnnetteDivision of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
(författare)
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Shanower, GregoryDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
(författare)
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Tolstorukov, Michael YCenter for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Children’s Hospital Informatics Program, Boston, Massachusetts 02115, USA
(författare)
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Luquette, Lovelace JCenter for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA
(författare)
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Xi, RuibinCenter for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA
(författare)
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Jung, Youngsook LCenter for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA
(författare)
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Park, Richard WCenter for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Graduate Program in Bioinformatics, Boston University, Boston, Massachusetts 02115, USA
(författare)
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Bishop, Eric PCenter for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Graduate Program in Bioinformatics, Boston University, Boston, Massachusetts 02115, USA
(författare)
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Canfield, Theresa KDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
(författare)
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Sandstrom, RichardDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
(författare)
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Thurman, Robert EDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
(författare)
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MacAlpine, David MDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
(författare)
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Stamatoyannopoulos, John ADepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, USA,Department of Medicine, University of Washington, Seattle, Washington 98195, USA
(författare)
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Kellis, ManolisMIT Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts 02139, USA,Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
(författare)
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Elgin, Sarah C RDepartment of Biology, Washington University in St Louis, St Louis, Missouri 63130, USA
(författare)
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Kuroda, Mitzi IDivision of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA,Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
(författare)
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Pirrotta, VincenzoDepartment of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
(författare)
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Karpen, Gary HDepartment of Molecular and Cell Biology, University of California at Berkeley, and Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California 94720, USA
(författare)
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Park, Peter JCenter for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA,Children’s Hospital Informatics Program, Boston, Massachusetts 02115, USA and Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA
(författare)
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Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USAChildren’s Hospital Informatics Program, Boston, Massachusetts 02115, USA
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nature: Springer Science and Business Media LLC471:7339, s. 480-4850028-08361476-4687
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Till lärosätets databas
- Av författaren/redakt...
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Kharchenko, Pete ...
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Alekseyenko, Art ...
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Schwartz, Yuri B
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Minoda, Aki
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Riddle, Nicole C
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Ernst, Jason
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visa fler...
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Sabo, Peter J
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Larschan, Erica
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Gorchakov, Andre ...
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Gu, Tingting
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Linder-Basso, Da ...
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Plachetka, Annet ...
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Shanower, Gregor ...
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Tolstorukov, Mic ...
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Luquette, Lovela ...
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Xi, Ruibin
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Jung, Youngsook ...
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Park, Richard W
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Bishop, Eric P
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Canfield, Theres ...
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Sandstrom, Richa ...
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Thurman, Robert ...
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MacAlpine, David ...
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Stamatoyannopoul ...
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Kellis, Manolis
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Elgin, Sarah C R
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Kuroda, Mitzi I
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Pirrotta, Vincen ...
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Karpen, Gary H
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Park, Peter J
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Nature
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Umeå universitet