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Polycomb complexes ...
Polycomb complexes and epigenetic states
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- Schwartz, Yuri B (författare)
- Department of Molecular Biology and Biochemistry, Rutgers University, New Jersey, U.S.A.
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Pirrotta, Vincenzo (författare)
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Department of Molecular Biology and Biochemistry, Rutgers University, New Jersey, US.A. (creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: Current Opinion in Cell Biology. - : Elsevier BV. - 0955-0674 .- 1879-0410. ; 20:3, s. 266-273
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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Abstract
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- Important advances in the study of Polycomb Group (PcG) complexes in the past two years have focused on the role of this repressive system in programing the genome. Genome-wide analyses have shown that PcG mechanisms control a large number of genes regulating many cellular functions and all developmental pathways. Current evidence shows that, contrary to the classical picture of their role, PcG complexes do not set a repressed chromatin state that is maintained throughout development but have a much more dynamic role. PcG target genes can become repressed or be reactivated or exist in intermediate states. What controls the balance between repression and derepression is a crucial question in understanding development and differentiation in higher organisms.
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