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Reproductive risk f...
Reproductive risk factors and endometrial cancer : the European prospective investigation into cancer and nutrition
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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Wiley,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-46385
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46385URI
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https://doi.org/10.1002/ijc.25050DOI
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https://lup.lub.lu.se/record/1630418URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Endometrial cancer risk has been associated with reproductive factors (age at menarche, age at menopause, parity, age at first and last birth, time since last birth and use of oral contraceptives (OCs)]. However, these factors are closely interrelated and whether they act independently still requires clarification. We conducted a study to examine the association of menstrual and reproductive variables with the risk of endometrial cancer among the European Prospective Investigation into Cancer and Nutrition (EPIC). Among the 302,618 women eligible for the study, 1,017 incident endometrial cancer cases were identified. A reduction in endometrial cancer risk was observed in women with late menarche, early menopause, past OC use, high parity and a shorter time since last full-term pregnancy (FTP). No association was observed for duration of breast feeding after adjustment for number of FTP or for abortion (spontaneous or induced). After mutual adjustment, late age at menarche, early age at menopause and duration of OC use showed similar risk reductions of 7-8% per year of menstrual life, whereas the decreased risk associated with cumulative duration of FTPs was stronger (22% per year). In conclusion, our findings confirmed a reduction in risk of endometrial cancer with factors associated with a lower cumulative exposure to estrogen and/or higher exposure to progesterone, such as increasing number of FTPs and shorter menstrual lifespan and, therefore, support an important role of hormonal mechanisms in endometrial carcinogenesis.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Allen, Naomi
(author)
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Kaaks, Rudolf
(author)
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Bakken, Kjersti
(author)
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Lund, Eiliv
(author)
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Tjonneland, Anne
(author)
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Olsen, Anja
(author)
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Overvad, Kim
(author)
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Clavel-Chapelon, Francoise
(author)
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Fournier, Agnes
(author)
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Chabbert-Buffet, Nathalie
(author)
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Boeing, Heiner
(author)
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Schütze, Madlen
(author)
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Trichopoulou, Antonia
(author)
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Trichopoulos, Dimitrios
(author)
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Lagiou, Pagona
(author)
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Palli, Domenico
(author)
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Krogh, Vittorio
(author)
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Tumino, Rosario
(author)
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Vineis, Paolo
(author)
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Mattiello, Amalia
(author)
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Bueno-de-Mesquita, H Bas
(author)
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Onland-Moret, N Charlotte
(author)
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Peeters, Petra H M
(author)
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Dumeaux, Vanessa
(author)
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Redondo, Maria-Luisa
(author)
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Duell, Eric
(author)
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Sanchez-Cantalejo, Emilio
(author)
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Arriola, Larraitz
(author)
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Chirlaque, Maria-Dolores
(author)
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Ardanaz, Eva
(author)
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Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)smi-jma
(author)
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Borgquist, SigneLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)ront-sbo
(author)
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Lukanova, AnnieUmeå universitet,Näringsforskning
(author)
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Lundin, EvaUmeå universitet,Patologi(Swepub:umu)evlu0001
(author)
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Khaw, Kay-Tee
(author)
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Wareham, Nicholas
(author)
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Key, Tim
(author)
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Chajes, Veronique
(author)
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Rinaldi, Sabina
(author)
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Slimani, Nadia
(author)
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Mouw, Traci
(author)
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Gallo, Valentina
(author)
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Riboli, Elio
(author)
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KirurgiForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:International Journal of Cancer: Wiley127:2, s. 442-4510020-71361097-0215
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Dossus, Laure
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Allen, Naomi
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Kaaks, Rudolf
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Bakken, Kjersti
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Lund, Eiliv
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Tjonneland, Anne
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Olsen, Anja
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Overvad, Kim
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Clavel-Chapelon, ...
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Fournier, Agnes
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Chabbert-Buffet, ...
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Boeing, Heiner
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Schütze, Madlen
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Trichopoulou, An ...
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Trichopoulos, Di ...
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Lagiou, Pagona
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Palli, Domenico
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Krogh, Vittorio
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Tumino, Rosario
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Vineis, Paolo
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Mattiello, Amali ...
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Bueno-de-Mesquit ...
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Onland-Moret, N ...
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Peeters, Petra H ...
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Dumeaux, Vanessa
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Redondo, Maria-L ...
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Duell, Eric
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Sanchez-Cantalej ...
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Arriola, Larrait ...
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Chirlaque, Maria ...
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Ardanaz, Eva
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Manjer, Jonas
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Borgquist, Signe
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Lukanova, Annie
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Lundin, Eva
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Key, Tim
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Chajes, Veroniqu ...
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Rinaldi, Sabina
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Slimani, Nadia
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Mouw, Traci
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Gallo, Valentina
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Riboli, Elio
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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Umeå University
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Lund University