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Correlation between...
Correlation between CA-125 serum level and response by RECIST in a phase III recurrent ovarian cancer study
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- Herzog, Thomas J. (författare)
- Columbia University College of Physicians and Surgeons, New York, NY, USA
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- Vermorken, Jan B. (författare)
- Antwerp University Hospital, Edegem, Belgium
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- Pujade-Lauraine, Eric (författare)
- Hôspital Hotel-Dieu, Paris, France
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- Provencher, Diane M. (författare)
- Hôpital Notre-Dame, Montréal (Qc) H2L 4M1, Canada
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- Jagiello-Gruszfeld, Agnieszka (författare)
- Memorial Cancer Center, Warszawa, Poland
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- Kong, Beihua (författare)
- Qilu Hospital, Shandong University, Shandong, China
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- Boman, Karin (författare)
- Umeå universitet,Onkologi
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- Park, Youn Choi (författare)
- Johnson and Johnson Pharmaceutical Research and Development, L.L.C., Raritan, NJ, USA
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- Parekh, Trilok (författare)
- Johnson and Johnson Pharmaceutical Research and Development, L.L.C., Raritan, NJ, USA
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- Lebedinsky, Claudia (författare)
- PharmaMar, Colmenar Viejo, Madrid, Spain
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- Gomez, Javier (författare)
- PharmaMar, Colmenar Viejo, Madrid, Spain
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- Monk, Bradley J. (författare)
- Creighton University School of Medicine at St. Joseph's Hospital and Medical Center, a member of Catholic Healthcare West, Phoenix, AZ, USA
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(creator_code:org_t)
- New York : Elsevier BV, 2011
- 2011
- Engelska.
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Ingår i: Gynecologic Oncology. - New York : Elsevier BV. - 0090-8258 .- 1095-6859. ; 122:2, s. 350-355
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives: To evaluate in a large phase III recurrent ovarian cancer trial (OVA-301): 1) the concordance between CA-125 level vs. best overall response (OR) and progression-free survival (PFS) determined by radiological assessment 2) the impact of early CA-125 changes over the subsequent radiological response, and 3) the prognostic value of CA-125 response and CA-125 PFS to predict radiological response and PFS. Methods: Assessment of response in the entire randomized population was performed by the Response Evaluation Criteria in Solid Tumors 1.0 (RECIST) and modified Rustin criteria for CA-125 determination. Results: Most CA-125 decreases were observed in RECIST responders (82% of patients treated with the combination and 74% in the PLD alone). CA-125 progression preceded REC1ST progression in 35% of patients with a median lead time of 8.4 weeks. A high concordance rate between CA-125 PFS status at 4 months (PFS4) and CA-125 response as a predictor of PFS4 (87%) and radiological response (79%) was found in the combination, with high positive predictive value for radiological PFS4 (92%) and high negative predictive value for OR (90%). An early CA-125 decrease was predictive for the ultimate response since it was found in a high rate of RECIST responders. Conclusion: Radiological response was preceded by a favorable predictive CA-125 decrease in a high proportion of patients, suggesting that CA-125 evaluation may be an appropriate tool for tumor assessment in patients with ovarian cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- CA-125
- Rustin criteria
- Platinum
- Relapsed ovarian cancer
- Trabectedin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Herzog, Thomas J ...
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Vermorken, Jan B ...
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Pujade-Lauraine, ...
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Provencher, Dian ...
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Jagiello-Gruszfe ...
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Kong, Beihua
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Boman, Karin
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Park, Youn Choi
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Parekh, Trilok
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Lebedinsky, Clau ...
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Gomez, Javier
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Monk, Bradley J.
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