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- Schlehofer, B (author)
Primary brain tumours and specific serum immunoglobulin E : a case-control study nested in the European prospective investigation into cancer and nutrition cohort
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- 2011-07-05
- Wiley,2011
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-47509
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-47509URI
- https://doi.org/10.1111/j.1398-9995.2011.02670.xDOI
- https://lup.lub.lu.se/record/2059046URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- ABSTRACT: Background: Case-control studies suggest that patients with allergic diseases have a lower risk of developing glioma but not meningioma or schwannoma. However, those data can be differentially biased. Prospective studies with objective measurements of immunologic biomarkers, like immunoglobulin E (IgE), in blood obtained before cancer diagnosis could help to clarify whether an aetiological association exists. Methods: The present case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) measured specific serum IgE as a biomarker for the most common inhalant allergens in 275 glioma, 175 meningioma and 49 schwannoma cases and 963 matched controls using the ImmunoCAP specific IgE test. Subjects with an IgE level ≥0.35 kUA/l (kilo antibody units per litre) were classified as sensitized by allergens. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by adjusted conditional logistic regression models for each tumour subtype. The effect of dose-response relationship was assessed in five increasing IgE level categories to estimate P-values for trend. Results: The risk of glioma was inversely related to allergic sensitization (OR = 0.73; 95% CI 0.51-1.06), especially pronounced in women (OR = 0.53; 95% CI 0.30-0.95). In dose-response analyses, for high-grade glioma, the lowest OR was observed in sera with the highest IgE levels (P for trend = 0.04). No association was seen for meningioma and schwannoma. Conclusion: The results, based on serum samples prospectively collected in a cohort study, provide some support for the hypothesis that individuals with allergic sensitization are at reduced risk of glioma and confirm results from previous case-control studies.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
- allergens
- brain tumours
- epidemiology
- immunoglobulin E
- immunologic tests
Added entries (persons, corporate bodies, meetings, titles ...)
- Siegmund, B (author)
- Linseisen, J (author)
- Schüz, J (author)
- Rohrmann, S (author)
- Becker, S (author)
- Michaud, D (author)
- Melin, BeatriceUmeå universitet,Onkologi(Swepub:umu)bema0010 (author)
- Bas Bueno-de-Mesquita, H (author)
- Peeters, P H M (author)
- Vineis, P (author)
- Tjönneland, A (author)
- Olsen, A (author)
- Overvad, K (author)
- Romieu, I (author)
- Boeing, H (author)
- Aleksandrova, K (author)
- Trichopoulou, A (author)
- Bamia, C (author)
- Lagiou, P (author)
- Sacerdote, C (author)
- Palli, D (author)
- Panico, S (author)
- Sieri, S (author)
- Tumino, R (author)
- Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)smi-jma (author)
- Rodriguez, L (author)
- Dorronsoro, M (author)
- Duell, E J (author)
- Chirlaque, M-D (author)
- Barricarte, A (author)
- Borgquist, SigneLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)ront-sbo (author)
- Manjer, J (author)
- Gallo, V (author)
- Allen, N E (author)
- Key, T J (author)
- Riboli, E (author)
- Kaaks, R (author)
- Wahrendorf, J (author)
- Umeå universitetOnkologi (creator_code:org_t)
Related titles
- In:Allergy. European Journal of Allergy and Clinical Immunology: Wiley66:11, s. 1434-14410105-45381398-9995
Internet link
- https://www.zora.uzh.ch/id/eprint/54311/1/EPIC_IGE_brain2011.pdf
- http://www.ncbi.nlm.nih.gov/pubmed/21726235?dopt=AbstractFULLTEXT
- http://dx.doi.org/10.1111/j.1398-9995.2011.02670.xFULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-47509
- https://doi.org/10.1111/j.1398-9995.2011.02670.x
- https://lup.lub.lu.se/record/2059046
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- Michaud, D
- Melin, Beatrice
- Bas Bueno-de-Mes ...
- Peeters, P H M
- Vineis, P
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- Olsen, A
- Overvad, K
- Romieu, I
- Boeing, H
- Aleksandrova, K
- Trichopoulou, A
- Bamia, C
- Lagiou, P
- Sacerdote, C
- Palli, D
- Panico, S
- Sieri, S
- Tumino, R
- Manjer, Jonas
- Rodriguez, L
- Dorronsoro, M
- Duell, E J
- Chirlaque, M-D
- Barricarte, A
- Borgquist, Signe
- Manjer, J
- Gallo, V
- Allen, N E
- Key, T J
- Riboli, E
- Kaaks, R
- Wahrendorf, J
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