Genome-wide association study identifies new prostate cancer susceptibility loci

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Schumacher, Fredrick R. (author)

Genome-wide association study identifies new prostate cancer susceptibility loci

Article/chapterEnglish2011

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2011-07-08
London :IRL Press,2011
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LIBRIS-ID:oai:DiVA.org:umu-47641
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-47641URI
https://doi.org/10.1093/hmg/ddr295DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:123200258URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade >= 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on in silico replication of 4679 SNPs (Stage 1, P < 0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, P = 4.3 x 10(-8)). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, P = 8.6 x 10(-9)). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity P = 0.72 and P = 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes.

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Berndt, Sonja I. (author)
Siddiq, Afshan (author)
Jacobs, Kevin B. (author)
Wang, Zhaoming (author)
Lindstrom, Sara (author)
Stevens, Victoria L. (author)
Chen, Constance (author)
Mondul, Alison M. (author)
Travis, Ruth C. (author)
Stram, Daniel O. (author)
Eeles, Rosalind A. (author)
Easton, Douglas F. (author)
Giles, Graham (author)
Hopper, John L. (author)
Neal, David E. (author)
Hamdy, Freddie C. (author)
Donovan, Jenny L. (author)
Muir, Kenneth (author)
Al Olama, Ali Amin (author)
Kote-Jarai, Zsofia (author)
Guy, Michelle (author)
Severi, Gianluca (author)
Gronberg, HenrikKarolinska Institutet (author)
Isaacs, William B. (author)
Karlsson, RobertKarolinska Institutet (author)
Wiklund, FredrikKarolinska Institutet (author)
Xu, Jianfeng (author)
Allen, Naomi E. (author)
Andriole, Gerald L. (author)
Barricarte, Aurelio (author)
Boeing, Heiner (author)
Bueno-de-Mesquita, H. Bas (author)
Crawford, E. David (author)
Diver, W. Ryan (author)
Gonzalez, Carlos A. (author)
Gaziano, J. Michael (author)
Giovannucci, Edward L. (author)
Johansson, MattiasUmeå universitet,Urologi och andrologi,International Agency for Research on Cancer (IARC), Lyon, France(Swepub:umu)masmas97 (author)
Le Marchand, Loic (author)
Ma, Jing (author)
Sieri, Sabina (author)
Stattin, PärUmeå universitet,Urologi och andrologi(Swepub:umu)past0003 (author)
Stampfer, Meir J. (author)
Tjonneland, Anne (author)
Vineis, Paolo (author)
Virtamo, Jarmo (author)
Vogel, Ulla (author)
Weinstein, Stephanie J. (author)
Yeager, Meredith (author)
Thun, Michael J. (author)
Kolonel, Laurence N. (author)
Henderson, Brian E. (author)
Albanes, Demetrius (author)
Hayes, Richard B. (author)
Feigelson, Heather Spencer (author)
Riboli, Elio (author)
Hunter, David J. (author)
Chanock, Stephen J. (author)
Haiman, Christopher A. (author)
Kraft, Peter (author)
Karolinska InstitutetUrologi och andrologi (creator_code:org_t)

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In:Human Molecular GeneticsLondon : IRL Press20:19, s. 3867-38750964-69061460-2083

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By the author/editor: Schumacher, Fred ...; Berndt, Sonja I.; Siddiq, Afshan; Jacobs, Kevin B.; Wang, Zhaoming; Lindstrom, Sara; show more...; Stevens, Victori ...; Chen, Constance; Mondul, Alison M ...; Travis, Ruth C.; Stram, Daniel O.; Eeles, Rosalind ...; Easton, Douglas ...; Giles, Graham; Hopper, John L.; Neal, David E.; Hamdy, Freddie C ...; Donovan, Jenny L ...; Muir, Kenneth; Al Olama, Ali Am ...; Kote-Jarai, Zsof ...; Guy, Michelle; Severi, Gianluca; Gronberg, Henrik; Isaacs, William ...; Karlsson, Robert; Wiklund, Fredrik; Xu, Jianfeng; Allen, Naomi E.; Andriole, Gerald ...; Barricarte, Aure ...; Boeing, Heiner; Bueno-de-Mesquit ...; Crawford, E. Dav ...; Diver, W. Ryan; Gonzalez, Carlos ...; Gaziano, J. Mich ...; Giovannucci, Edw ...; Johansson, Matti ...; Le Marchand, Loi ...; Ma, Jing; Sieri, Sabina; Stattin, Pär; Stampfer, Meir J ...; Tjonneland, Anne; Vineis, Paolo; Virtamo, Jarmo; Vogel, Ulla; Weinstein, Steph ...; Yeager, Meredith; Thun, Michael J.; Kolonel, Laurenc ...; Henderson, Brian ...; Albanes, Demetri ...; Hayes, Richard B ...; Feigelson, Heath ...; Riboli, Elio; Hunter, David J.; Chanock, Stephen ...; Haiman, Christop ...; Kraft, Peter; show less...

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

Articles in the publication: Human Molecular ...

By the university: Umeå University; Karolinska Institutet

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