SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Pileggi Antonello)
 

Search: WFRF:(Pileggi Antonello) > (2011) > The thyroid hormone...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Medina, Mayrin C. (author)

The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human β-cells and its targeted inactivation impairs insulin secretion

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-08-09
  • Baltimore :Williams & Wilkins,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-48290
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-48290URI
  • https://doi.org/10.1210/en.2011-1210DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Deiodinases are selenoproteins that activate or inactivate thyroid hormone. During vertebrate development, these pathways control thyroid hormone action in a cell-specific fashion explaining how systemic thyroid hormone can affect local control of tissue embryogenesis. Here we investigated the role of the thyroid hormone-inactivating deiodinase (D3) in pancreatic islet function and glucose homeostasis. D3 expression was determined by real-time PCR, immunofluorescence, and enzyme activity. Embryonic and adult wild-type mice and Mice with targeted disruption of Dio3 gene (D3KO) as well as human fetal pancreas and adult islets were studied. Insulin secretion was evaluated in adult mouse isolated islets. We found Dio3 gene expression and protein highly expressed in embryonic and adult pancreatic islets, predominantly in beta-cells in both humans and mice. However, mRNA levels were barely detectable for both the thyroid hormone-activating deiodinases types 1 and 2. D3KO animals were found to be glucose intolerant due to in vitro and in vivo impaired glucose-stimulated insulin secretion, without changes in peripheral sensitivity to insulin. D3KO neonatal (postnatal day 0) and adult pancreas exhibited reduced total islet area due to reduced beta-cell mass, insulin content, and impaired expression of key beta-cells genes. D3 expression in perinatal pancreatic beta-cells prevents untimely exposure to thyroid hormone, the absence of which leads to impaired beta-cell function and subsequently insulin secretion and glucose homeostasis. An analogous role is likely in humans, given the similar D3 expression pattern.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Molina, Judith (author)
  • Gadea, Yelena (author)
  • Fachado, Alberto (author)
  • Murillo, Monika (author)
  • Simovic, Gordana (author)
  • Pileggi, Antonello (author)
  • Hernandez, Arturo (author)
  • Edlund, HelenaUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)heed0001 (author)
  • Bianco, Antonio C. (author)
  • Umeå universitetUmeå centrum för molekylär medicin (UCMM) (creator_code:org_t)

Related titles

  • In:EndocrinologyBaltimore : Williams & Wilkins152:10, s. 3717-37270013-72271945-7170

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view