Search: WFRF:(Zeleniuch Jacquotte A.)
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Postmenopausal circ...
Postmenopausal circulating levels of 2- and 16α-hydroxyestrone and risk of endometrial cancer
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Zeleniuch-Jacquotte, A (author)
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Shore, R E (author)
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Afanasyeva, Y (author)
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Lukanova, A (author)
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Sieri, S (author)
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Koenig, K L (author)
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- Idahl, Annika (author)
- Umeå universitet,Obstetrik och gynekologi
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Krogh, V (author)
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Liu, M (author)
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- Ohlson, Nina (author)
- Umeå universitet,Patologi
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Muti, P (author)
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Arslan, A A (author)
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- Lenner, Per (author)
- Umeå universitet,Onkologi
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Berrino, F (author)
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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Toniolo, P (author)
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- Lundin, Eva (author)
- Umeå universitet,Patologi
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(creator_code:org_t)
- 2011-09-27
- 2011
- English.
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In: British Journal of Cancer. - London : Harcourt Publishers. - 0007-0920 .- 1532-1827. ; 105:9, s. 1458-1464
- Related links:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: It has been suggested that the relative importance of oestrogen-metabolising pathways may affect the risk of oestrogen-dependent tumours including endometrial cancer. One hypothesis is that the 2-hydroxy pathway is protective, whereas the 16α-hydroxy pathway is harmful. Methods: We conducted a case-control study nested within three prospective cohorts to assess whether the circulating 2-hydroxyestrone : 16α-hydroxyestrone (2-OHE1 : 16α-OHE1) ratio is inversely associated with endometrial cancer risk in postmenopausal women. A total of 179 cases and 336 controls, matching cases on cohort, age and date of blood donation, were included. Levels of 2-OHE1 and 16α-OHE1 were measured using a monoclonal antibody-based enzyme assay. Results: Endometrial cancer risk increased with increasing levels of both metabolites, with odds ratios in the top tertiles of 2.4 (95% CI=1.3, 4.6; P(trend)=0.007) for 2-OHE1 and 1.9 (95% CI=1.1, 3.5; P(trend)=0.03) for 16α-OHE1 in analyses adjusting for endometrial cancer risk factors. These associations were attenuated and no longer statistically significant after further adjustment for oestrone or oestradiol levels. No significant association was observed for the 2-OHE1 : 16α-OHE1 ratio. Conclusion: Our results do not support the hypothesis that greater metabolism of oestrogen via the 2-OH pathway, relative to the 16α-OH pathway, protects against endometrial cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- endometrial cancer
- nested case–control study
- oestrogen metabolites
- 2-hydroxyestrone
- 16α-hydroxyestrone
- post-menopause
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zeleniuch-Jacquo ...
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Shore, R E
-
Afanasyeva, Y
-
Lukanova, A
-
Sieri, S
-
Koenig, K L
-
show more...
-
Idahl, Annika
-
Krogh, V
-
Liu, M
-
Ohlson, Nina
-
Muti, P
-
Arslan, A A
-
Lenner, Per
-
Berrino, F
-
Hallmans, Göran
-
Toniolo, P
-
Lundin, Eva
-
show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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British Journal ...
- By the university
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Umeå University