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  • Lilja, Mikael,1953-Umeå universitet,Allmänmedicin (author)

Higher leptin levels in Asian Indians than Creoles and Europids : a potential explanation for increased metabolic risk

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • 2010-02-02
  • Springer Science and Business Media LLC,2010
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-49380
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49380URI
  • https://doi.org/10.1038/ijo.2010.19DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND AND PURPOSE: Leptin predicts cardiovascular diseases and type 2 diabetes, diseases to which Asian Indians are highly susceptible. As a risk marker, leptin's intra-individual and seasonal stability is unstudied and only small studies have compared leptin levels in Asian Indians with other populations. The aim of this study was to explore ethnicity related differences in leptin levels and its intra-individual and seasonal stability. METHODS: Leptin and anthropometric data from the northern Sweden MONICA (3513 Europids) and the Mauritius Non-communicable Disease (2480 Asian Indians and Creoles) studies were used. In both studies men and women, 25- to 74-year old, participated in both an initial population survey and a follow-up after 5-13 years. For the analysis of seasonal leptin variation, a subset of 1780 participants, 30- to 60-year old, in the Västerbotten Intervention Project was used. RESULTS: Asian Indian men and women had higher levels of leptin, leptin per body mass index (BMI) unit (leptin/BMI) or per cm in waist circumference (WC; leptin/waist) than Creoles and Europids when adjusted for BMI (all P<0.0005) or WC (all P<0.005). In men, Creoles had higher leptin, leptin/BMI and leptin/waist than Europids when adjusted for BMI or WC (all P<0.0005). In women, Creoles had higher leptin/BMI and leptin/waist than Europids only when adjusted for WC (P<0.0005). Asian Indian ethnicity in both sexes, and Creole ethnicity in men, was independently associated with high leptin levels. The intra-class correlation for leptin was similar (0.6-0.7), independently of sex, ethnicity or follow-up time. No seasonal variation in leptin levels was seen. CONCLUSION: Asian Indians have higher levels of leptin, leptin/BMI and leptin/waist than Creoles and Europids. Leptin has a high intra-individual stability and seasonal leptin variation does not appear to explain the ethnic differences observed here

Subject headings and genre

  • leptin
  • ethnicity
  • season
  • intra-individual stability

Added entries (persons, corporate bodies, meetings, titles ...)

  • Rolandsson, OlovUmeå universitet,Allmänmedicin(Swepub:umu)olro0005 (author)
  • Shaw, JEBaker IDI Heart and diabetes institute, Melbourne (author)
  • Pauvaday, VassenMinistry of Health and Quality of Life, Port Louis, Mauritiu (author)
  • Cameron, AdrianBaker IDI, Heart and diabetes institute, Melbourne (author)
  • Tuomilehto, JDepartment of Public Health, University of Helsinki (author)
  • Alberti, KGMMDepartment of Endocrinology and Metabolic Medicine, Imperial College, London (author)
  • Zimmet, PaulBaker IDI, Heart and diabetes institute, Melbourne (author)
  • Söderberg, StefanUmeå universitet,Medicin(Swepub:umu)stso0001 (author)
  • Umeå universitetAllmänmedicin (creator_code:org_t)

Related titles

  • In:International Journal of Obesity: Springer Science and Business Media LLC34:5, s. 878-8850307-05651476-5497

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