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Prediagnostic circu...
Prediagnostic circulating parathyroid hormone concentration and colorectal cancer in the European Prospective Investigation into Cancer and Nutrition cohort
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Fedirko, Veronika (author)
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Riboli, Elio (author)
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Bueno-de-Mesquita, H Bas (author)
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Rinaldi, Sabina (author)
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Pischon, Tobias (author)
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Norat, Teresa (author)
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Jansen, Eugène H J M (author)
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van Duijnhoven, Fränzel J B (author)
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Tjønneland, Anne (author)
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Olsen, Anja (author)
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Overvad, Kim (author)
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Boutron-Ruault, Marie-Christine (author)
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Clavel-Chapelon, Françoise (author)
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Engel, Pierre (author)
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Kaaks, Rudolf (author)
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Teucher, Birgit (author)
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Boeing, Heiner (author)
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Buijsse, Brian (author)
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Trichopoulou, Antonia (author)
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Trichopoulos, Dimitrios (author)
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Lagiou, Pagona (author)
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Sieri, Sabina (author)
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Vineis, Paolo (author)
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Panico, Salvatore (author)
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Palli, Domenico (author)
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Tumino, Rosario (author)
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van Gils, Carla H (author)
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Peeters, Petra H M (author)
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Chirlaque, Maria-Dolores (author)
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Gurrea, Aurelio Barricarte (author)
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Rodríguez, Laudina (author)
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Molina-Montes, Esther (author)
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Dorronsoro, Miren (author)
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Bonet, Catalina (author)
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- Palmqvist, Richard (author)
- Umeå universitet,Patologi
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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Key, Timothy J (author)
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Tsilidis, Konstantinos K (author)
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Khaw, Kay-Tee (author)
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Romieu, Isabelle (author)
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Straif, Kurt (author)
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Wark, Petra A (author)
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Romaguera, Dora (author)
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Jenab, Mazda (author)
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(creator_code:org_t)
- American Association for Cancer Research, 2011
- 2011
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 20:5, s. 767-778
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Parathyroid hormone (PTH) has been proposed to play a promoting role in carcinogenesis. However, no epidemiologic studies have yet directly investigated its role in colorectal cancer (CRC). METHODS: A case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort was conducted with 1,214 incident, sporadic CRC cases matched to 1,214 controls. Circulating prediagnostic PTH and 25-hydroxy vitamin D [25(OH)D] concentrations were measured by enzyme-linked immunosorbent assays. Detailed dietary and lifestyle questionnaire data were collected at baseline. Multivariable conditional logistic regression was used to estimate the incidence rate ratio (RR) with 95% confidence intervals (95% CI) for the association between circulating PTH and CRC risk. RESULTS: In multivariate analyses [including adjustment for 25(OH)D concentration] with a priori defined cutoff points, high levels of serum PTH (≥65 ng/L) compared with medium PTH levels of 30-65 ng/L were associated with increased CRC risk (RR = 1.41, 95% CI: 1.03-1.93). In analyses by sex, the CRC risk was 1.77 (95% CI: 1.14-2.75) and 1.15 (95% CI: 0.73-1.84) in men and women, respectively (P(heterogeneity) = 0.01). In subgroup analyses by anatomical subsite, the risk for colon cancer was RR = 1.56, 95% CI: 1.03-2.34, and for rectal cancer RR = 1.20, 95% CI: 0.72-2.01 (P(heterogeneity) = 0.21). Effect modification by various risk factors was examined. CONCLUSIONS: The results of this study suggest that high serum PTH levels may be associated with incident, sporadic CRC in Western European populations, and in particular among men. IMPACT: To our knowledge, this is the first study on PTH and CRC. The role of PTH in carcinogenesis needs to be further investigated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- Pathology
- patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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Fedirko, Veronik ...
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Riboli, Elio
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Bueno-de-Mesquit ...
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Rinaldi, Sabina
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Pischon, Tobias
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Norat, Teresa
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show more...
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Jansen, Eugène H ...
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van Duijnhoven, ...
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Tjønneland, Anne
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Olsen, Anja
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Overvad, Kim
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Boutron-Ruault, ...
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Clavel-Chapelon, ...
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Engel, Pierre
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Kaaks, Rudolf
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Teucher, Birgit
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Boeing, Heiner
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Buijsse, Brian
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Trichopoulou, An ...
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Trichopoulos, Di ...
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Lagiou, Pagona
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Sieri, Sabina
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Vineis, Paolo
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Panico, Salvator ...
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Palli, Domenico
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Tumino, Rosario
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van Gils, Carla ...
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Peeters, Petra H ...
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Chirlaque, Maria ...
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Gurrea, Aurelio ...
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Rodríguez, Laudi ...
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Molina-Montes, E ...
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Dorronsoro, Mire ...
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Bonet, Catalina
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Palmqvist, Richa ...
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Hallmans, Göran
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Key, Timothy J
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Tsilidis, Konsta ...
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Khaw, Kay-Tee
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Romieu, Isabelle
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Straif, Kurt
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Wark, Petra A
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Romaguera, Dora
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Jenab, Mazda
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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Cancer Epidemiol ...
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Umeå University