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Adipose tissue IL-8...
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Alvehus, MalinUmeå universitet,Medicin,Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå University, Umeå, Sweden
(author)
Adipose tissue IL-8 is increased in normal weight women after menopause and reduced after gastric bypass surgery in obese women
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-10-05
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Wiley-Blackwell,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-51103
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51103URI
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https://doi.org/10.1111/j.1365-2265.2011.04322.xDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-72236URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Objective: The menopausal transition is characterized by increased body fat accumulation, including redistribution from peripheral to central fat depots. This distribution is associated with an increased risk of type 2 diabetes and cardiovascular disease which are linked to low-grade inflammation. We determined whether postmenopausal women have higher levels of inflammatory markers, compared to premenopausal women. We also wanted to determine if these markers are reduced by stable weight loss in obese women. Design and methods: Anthropometric data, blood samples, and subcutaneous adipose tissue biopsies were collected from normal weight premenopausal and postmenopausal women and obese women before and 2 years after gastric bypass surgery. Serum protein levels and adipose tissue gene expression of inflammatory markers were investigated. Results: IL-8 expression in adipose tissue and circulating levels were higher in postmenopausal versus premenopausal women. IL-8 expression was associated with waist circumference, independent of menopausal status. IL-6 expression and serum levels of monocyte chemoattractant protein (MCP)-1 were higher in postmenopausal versus premenopausal women. Two years after gastric bypass surgery, adipose expression of IL-8, tumor necrosis factor-α, and MCP-1 decreased significantly. Serum insulin levels were associated with inflammation-related gene expression before gastric bypass surgery, but these associations disappeared after surgery. Conclusion: Postmenopausal women have an increased inflammatory response in the subcutaneous fat and circulation. Inflammatory markers in adipose tissue decreased significantly after surgery-induced weight loss. This effect may be beneficial for metabolic control and reduced cardiovascular risk after weight loss. © 2011 Blackwell Publishing Ltd.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Simonyte, KotrynaUmeå universitet,Medicin,Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå University, Umeå, Sweden(Swepub:umu)kosi0001
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Andersson, TheréseUmeå universitet,Medicin,Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå University, Umeå, Sweden(Swepub:umu)theann98
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Söderström, IngegerdUmeå universitet,Medicin,Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå University, Umeå, Sweden(Swepub:umu)inso0001
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Burén, JonasUmeå universitet,Medicin,Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå University, Umeå, Sweden(Swepub:umu)jobu0003
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Rask, Eva,1958-Örebro Univ Hosp, Dept Med, Örebro, Sweden,Department of Medicine, Örebro University Hospital, Örebro, Sweden(Swepub:oru)erk
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Mattsson, CeciliaUmeå universitet,Medicin,Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå University, Umeå, Sweden(Swepub:umu)cema0004
(author)
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Olsson, TommyUmeå universitet,Medicin,Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå University, Umeå, Sweden(Swepub:umu)tool0003
(author)
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Umeå universitetMedicin
(creator_code:org_t)
Related titles
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In:Clinical Endocrinology: Wiley-Blackwell77:5, s. 684-6900300-06641365-2265
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