Search: id:"swepub:oai:DiVA.org:umu-51284" >
Human primary bronc...
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Ekstrand-Hammarström, Barbro
(author)
Human primary bronchial epithelial cells respond differently to titanium dioxide nanoparticles than the lung epithelial cell lines A549 and BEAS-2B
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2011-07-25
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Informa UK Limited,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-51284
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51284URI
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https://doi.org/10.3109/17435390.2011.598245DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We have compared the cellular uptake and responses of five preparations of nanocrystalline titanium dioxide (TiO(2)) between normal human bronchial epithelial (NHBE) cells and epithelial cell lines (A549 and BEAS-2B). The P25 nanoparticles, containing both anatase and rutile modifications, induced reactive oxygen species (ROS) and secretion of the neutrophil chemoattractant IL-8 in all three cell types used. Pure anatase and rutile particles provoked differential IL-8 response in A549 and no response in BEAS-2B cells despite similar formation of ROS. The pure TiO(2) modifications also provoked release of the inflammatory mediators: IL-6, G-CSF and VEGF, in NHBE cells but not in the two cell lines. We conclude that the responsiveness of lung epithelial cells is strongly dependent on both the physicochemical properties of TiO(2) nanoparticles and the type of responder cells. The differential pro-inflammatory responsiveness of primary lung epithelial cells compared with immortalized cell lines should be considered in the assessment of adverse reactions to inhaled nanoparticles.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Akfur, Christine M
(author)
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Andersson, Per Ola
(author)
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Lejon, Christian
(author)
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Österlund, Lars
(author)
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Bucht, AndersUmeå universitet,Lungmedicin(Swepub:umu)anbu0006
(author)
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Umeå universitetLungmedicin
(creator_code:org_t)
Related titles
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In:Nanotoxicology: Informa UK Limited6:6, s. 623-6341743-53901743-5404
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