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Sökning: WFRF:(Renne Thomas) > Factor XII activati...

  • Kilinç, E (författare)

Factor XII activation is essential to sustain the procoagulant effects of particulate matter

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2011
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-51285
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51285URI
  • https://doi.org/10.1111/j.1538-7836.2011.04280.xDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:122866865URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: Particulate matter (PM) is a key component of ambient air pollution and has been associated with an increased risk of thrombotic events and mortality. The underlying mechanisms remain unclear. OBJECTIVES:  To study the mechanisms of PM-driven procoagulant activity in human plasma and to investigate mainly, the coagulation driven by ultrafine particles (UFPs; < 0.1 μm) in genetically modified mice. METHODS: Thrombin generation in response to PM of different sizes was assessed in normal human platelet-poor plasma, as well as in plasmas deficient in the intrinsic pathway proteases factors XII (FXII) or XI (FXI). In addition, UFPs were intratracheally instilled in wild-type (WT) and FXII-deficient (FXII(-/-) ) mice and plasma thrombin generation was analyzed in plasma from treated mice at 4 and 20 h post-exposure. RESULTS: In normal human plasma, thrombin generation was enhanced in the presence of PM, whereas PM-driven thrombin formation was completely abolished in FXII- and FXI-deficient plasma. UFPs induced a transient increase in tissue factor (TF)-driven thrombin formation at 4 h post-instillation in WT mice compared with saline instillation. Intratracheal instillation of UFPs resulted in a procoagulant response in WT mice plasma at 20 h, whereas it was entirely suppressed in FXII(-/-) mice. CONCLUSIONS:  Overall, the data suggest that PM promotes its early procoagulant actions mostly through the TF-driven extrinsic pathway of coagulation, whereas PM-driven long lasting thrombogenic effects are predominantly mediated via formation of activated FXII. Hence, FXII-driven thrombin formation may be relevant to an enhanced thrombotic susceptibility upon chronic exposure to PM in humans.

Ämnesord och genrebeteckningar

  • air pollution
  • blood coagulation
  • factor XII
  • intrinsic coagulation pathway
  • particulate matter
  • thrombin generation

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Van Oerle, R (författare)
  • Borissoff, J I (författare)
  • Oschatz, C (författare)
  • Gerlofs-Nijland, M E (författare)
  • Janssen, N A (författare)
  • Cassee, F R (författare)
  • Sandström, ThomasUmeå universitet,Lungmedicin(Swepub:umu)thsa0001 (författare)
  • Renné, TKarolinska Institutet (författare)
  • Ten Cate, H (författare)
  • Spronk, H M H (författare)
  • Umeå universitetLungmedicin (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Thrombosis and Haemostasis: Elsevier BV9:7, s. 1359-13671538-79331538-7836

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