A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23

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Wu, Xifeng (author)

A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23

Article/chapterEnglish2012

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2011-10-18
Oxford University Press (OUP),2012
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LIBRIS-ID:oai:DiVA.org:umu-51644
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51644URI
https://doi.org/10.1093/hmg/ddr479DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Renal cell carcinoma (RCC) is the most lethal urologic cancer. Only two common susceptibility loci for RCC have been confirmed to date. To identify additional RCC common susceptibility loci, we conducted an independent genome- wide association study (GWAS). We analyzed 533 191 single nucleotide polymorphisms (SNPs) for association with RCC in 894 cases and 1516 controls of European descent recruited from MD Anderson Cancer Center in the primary scan, and validated the top 500 SNPs in silico in 3772 cases and 8505 controls of European descent involved in the only published GWAS of RCC. We identified two common variants in linkage disequilibrium, rs718314 and rs1049380 (r(2) = 0.64, D' = 0.84), in the inositol 1,4,5-triphosphate receptor, type 2 (ITPR2) gene on 12p11.23 as novel susceptibility loci for RCC (P = 8.89 x 10(-10) and P = 6.07 x 10(-9), respectively, in meta-analysis) with an allelic odds ratio of 1.19 [95% confidence interval (CI): 1.13-1.26] for rs718314 and 1.18 (95% CI: 1.12-1.25) for rs1049380. It has been recently identified that rs718314 in ITPR2 is associated with waist-hip ratio (WHR) phenotype. To our knowledge, this is the first genetic locus associated with both cancer risk and WHR.

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Scelo, Ghislaine (author)
Purdue, Mark P. (author)
Rothman, Nathaniel (author)
Johansson, MattiasInternational Agency for Research on Cancer (IARC), Lyon, France(Swepub:umu)masmas97 (author)
Ye, Yuanqing (author)
Wang, Zhaoming (author)
Zelenika, Diana (author)
Moore, Lee E. (author)
Wood, Christopher G. (author)
Prokhortchouk, Egor (author)
Gaborieau, Valerie (author)
Jacobs, Kevin B. (author)
Chow, Wong-Ho (author)
Toro, Jorge R. (author)
Zaridze, David (author)
Lin, Jie (author)
Lubinski, Jan (author)
Trubicka, Joanna (author)
Szeszenia-Dabrowska, Neonilia (author)
Lissowska, Jolanta (author)
Rudnai, Peter (author)
Fabianova, Eleonora (author)
Mates, Dana (author)
Jinga, Viorel (author)
Bencko, Vladimir (author)
Slamova, Alena (author)
Holcatova, Ivana (author)
Navratilova, Marie (author)
Janout, Vladimir (author)
Boffetta, Paolo (author)
Colt, Joanne S. (author)
Davis, Faith G. (author)
Schwartz, Kendra L. (author)
Banks, Rosamonde E. (author)
Selby, Peter J. (author)
Harnden, Patricia (author)
Berg, Christine D. (author)
Hsing, Ann W. (author)
Grubb, Robert L., III (author)
Boeing, Heiner (author)
Vineis, Paolo (author)
Clavel-Chapelon, Francoise (author)
Palli, Domenico (author)
Tumino, Rosario (author)
Krogh, Vittorio (author)
Panico, Salvatore (author)
Duell, Eric J. (author)
Ramon Quiros, Jose (author)
Sanchez, Maria-Jose (author)
Navarro, Carmen (author)
Ardanaz, Eva (author)
Dorronsoro, Miren (author)
Khaw, Kay-Tee (author)
Allen, Naomi E. (author)
Bueno-de-Mesquita, H. Bas (author)
Peeters, Petra H. M. (author)
Trichopoulos, Dimitrios (author)
Linseisen, Jakob (author)
Ljungberg, BörjeUmeå universitet,Urologi och andrologi(Swepub:umu)bolj0001 (author)
Overvad, Kim (author)
Tjonneland, Anne (author)
Romieu, Isabelle (author)
Riboli, Elio (author)
Stevens, Victoria L. (author)
Thun, Michael J. (author)
Diver, W. Ryan (author)
Gapstur, Susan M. (author)
Pharoah, Paul D. (author)
Easton, Douglas F. (author)
Albanes, Demetrius (author)
Virtamo, Jarmo (author)
Vatten, Lars (author)
Hveem, Kristian (author)
Fletcher, Tony (author)
Koppova, Kvetoslava (author)
Cussenot, Olivier (author)
Cancel-Tassin, Geraldine (author)
Benhamou, Simone (author)
Hildebrandt, Michelle A. (author)
Pu, Xia (author)
Foglio, Mario (author)
Lechner, Doris (author)
Hutchinson, Amy (author)
Yeager, Meredith (author)
Fraumeni, Joseph F., Jr. (author)
Lathrop, Mark (author)
Skryabin, Konstantin G. (author)
McKay, James D. (author)
Gu, Jian (author)
Brennan, Paul (author)
Chanock, Stephen J. (author)
International Agency for Research on Cancer (IARC), Lyon, FranceUrologi och andrologi (creator_code:org_t)

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In:Human Molecular Genetics: Oxford University Press (OUP)21:2, s. 456-4620964-69061460-2083

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By the author/editor: Wu, Xifeng; Scelo, Ghislaine; Purdue, Mark P.; Rothman, Nathani ...; Johansson, Matti ...; Ye, Yuanqing; show more...; Wang, Zhaoming; Zelenika, Diana; Moore, Lee E.; Wood, Christophe ...; Prokhortchouk, E ...; Gaborieau, Valer ...; Jacobs, Kevin B.; Chow, Wong-Ho; Toro, Jorge R.; Zaridze, David; Lin, Jie; Lubinski, Jan; Trubicka, Joanna; Szeszenia-Dabrow ...; Lissowska, Jolan ...; Rudnai, Peter; Fabianova, Eleon ...; Mates, Dana; Jinga, Viorel; Bencko, Vladimir; Slamova, Alena; Holcatova, Ivana; Navratilova, Mar ...; Janout, Vladimir; Boffetta, Paolo; Colt, Joanne S.; Davis, Faith G.; Schwartz, Kendra ...; Banks, Rosamonde ...; Selby, Peter J.; Harnden, Patrici ...; Berg, Christine ...; Hsing, Ann W.; Grubb, Robert L. ...; Boeing, Heiner; Vineis, Paolo; Clavel-Chapelon, ...; Palli, Domenico; Tumino, Rosario; Krogh, Vittorio; Panico, Salvator ...; Duell, Eric J.; Ramon Quiros, Jo ...; Sanchez, Maria-J ...; Navarro, Carmen; Ardanaz, Eva; Dorronsoro, Mire ...; Khaw, Kay-Tee; Allen, Naomi E.; Bueno-de-Mesquit ...; Peeters, Petra H ...; Trichopoulos, Di ...; Linseisen, Jakob; Ljungberg, Börje; Overvad, Kim; Tjonneland, Anne; Romieu, Isabelle; Riboli, Elio; Stevens, Victori ...; Thun, Michael J.; Diver, W. Ryan; Gapstur, Susan M ...; Pharoah, Paul D.; Easton, Douglas ...; Albanes, Demetri ...; Virtamo, Jarmo; Vatten, Lars; Hveem, Kristian; Fletcher, Tony; Koppova, Kvetosl ...; Cussenot, Olivie ...; Cancel-Tassin, G ...; Benhamou, Simone; Hildebrandt, Mic ...; Pu, Xia; Foglio, Mario; Lechner, Doris; Hutchinson, Amy; Yeager, Meredith; Fraumeni, Joseph ...; Lathrop, Mark; Skryabin, Konsta ...; McKay, James D.; Gu, Jian; Brennan, Paul; Chanock, Stephen ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Urology and Neph ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: Human Molecular ...

By the university: Umeå University

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