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FGFR3, TERT and OTX...
FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study
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- Beukers, Willemien (författare)
- Erasmus MC, Dept Pathol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
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- van der Keur, Kirstin A. (författare)
- Erasmus MC, Dept Pathol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
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- Kandimalla, Raju (författare)
- Erasmus MC, Dept Pathol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
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- Vergouwe, Yvonne (författare)
- Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands.
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- Steyerberg, Ewout W. (författare)
- Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands.
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- Boormans, Joost L. (författare)
- Erasmus MC, Dept Urol, Rotterdam, Netherlands.
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- Jensen, Jorgen B. (författare)
- Aarhus Univ Hosp, Dept Urol, Aarhus, Denmark.
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- Lorente, Jose A. (författare)
- Hosp del Mar, Serv Urol, Barcelona, Spain.
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- Real, Francisco X. (författare)
- Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona, Spain.;Spanish Natl Canc Res Centre CNIO, Canc Cell Biol Programme, Epithelial Carcinogenesis Grp, Madrid, Spain.
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- Segersten, Ulrike (författare)
- Uppsala universitet,Urologkirurgi
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- Orntoft, Torben F. (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus, Denmark.
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- Malats, Nuria (författare)
- Spanish Natl Canc Res Centre CNIO, Canc Cell Biol Programme, Epithelial Carcinogenesis Grp, Madrid, Spain.
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- Malmström, Per-Uno (författare)
- Uppsala universitet,Urologkirurgi
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- Dyrskjot, Lars (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus, Denmark.
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- Zwarthoff, Ellen C. (författare)
- Erasmus MC, Dept Pathol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
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Erasmus MC, Dept Pathol, POB 2040, NL-3000 CA Rotterdam, Netherlands Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands. (creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2017
- 2017
- Engelska.
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Ingår i: Journal of Urology. - : Ovid Technologies (Wolters Kluwer Health). - 0022-5347 .- 1527-3792. ; 197:6, s. 1410-1418
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose: Patients with nonmuscle invasive bladder cancer are followed with frequent cystoscopies. In this study FGFR3, TERT and OTX1 were investigated as a diagnostic urinary marker combination during followup of patients with primary nonmuscle invasive bladder cancer.Materials and Methods: In this international, multicenter, prospective study 977 patients with nonmuscle invasive bladder cancer were included. A total of 2,496 urine samples were collected prior to cystoscopy during regular visits. Sensitivity was estimated to detect concomitant recurrences. Kaplan-Meier curves were used to estimate the development of future recurrences after urinalysis and a negative cystoscopy.Results: Sensitivity of the assay combination for recurrence detection was 57% in patients with primary low grade, nonmuscle invasive bladder cancer. However, sensitivity was 83% for recurrences that were pT1 or muscle invasive bladder cancer. Of the cases 2% progressed to muscle invasive bladder cancer. Sensitivity for recurrence detection in patients with primary high grade disease was 72% and 7% of them had progression to muscle invasive bladder cancer. When no concomitant tumor was found by cystoscopy, positive urine samples were more frequently followed by a recurrence over time compared to a negative urine sample (58% vs 36%, p < 0.001). High stage recurrences were identified within 1 year after a positive urine test and a negative cystoscopy.Conclusions: Recurrences in patients with primary nonmuscle invasive bladder cancer can be detected by a combination of urine assays. This study supports the value of urinalysis as an alternative diagnostic tool in patients presenting with low grade tumors and as a means to identify high stage tumors earlier.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- urinary bladder neoplasms
- neoplasm recurrence
- local
- urinalysis
- cystoscopy
- neoplasm invasiveness
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- art (ämneskategori)
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Beukers, Willemi ...
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van der Keur, Ki ...
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Kandimalla, Raju
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Vergouwe, Yvonne
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Steyerberg, Ewou ...
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Boormans, Joost ...
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Jensen, Jorgen B ...
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Lorente, Jose A.
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Real, Francisco ...
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Segersten, Ulrik ...
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Orntoft, Torben ...
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Malats, Nuria
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Malmström, Per-U ...
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Dyrskjot, Lars
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Zwarthoff, Ellen ...
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