Subarachnoid haemorrhage induces an inflammatory response followed by a delayed persisting increase in asymmetric dimethylarginine

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Rodling Wahlström, MarieUmeå universitet,Anestesiologi och intensivvård (author)

Subarachnoid haemorrhage induces an inflammatory response followed by a delayed persisting increase in asymmetric dimethylarginine

Article/chapterEnglish2012

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2012-08-31
Informa UK Limited,2012
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-55732
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-55732URI
https://doi.org/10.3109/00365513.2012.699098DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Object: Subarachnoid haemorrhage (SAH) is associated with an inflammatory systemic response and cardiovascular complications. Asymmetric dimethyl arginine (ADMA), an endogenous inhibitor of nitric oxide synthase, mediates vasoconstriction and might contribute to cerebral vasoconstriction and cardiovascular complications after SAH. ADMA is also involved in inflammation and induces endothelial dysfunction.The aim of this study was to evaluate whether and how CRP (marker for systemic inflammation) and ADMA increased in patients during the acute phase (first week) after SAH. The ADMA level was also assessed in the patients in a non-acute phase (three months), and in healthy controls.Methods: Prospective study of 20 patients with aneurysmal SAH. ADMA and CRP were followed daily during the first week after SAH and a follow up sample for ADMA was obtained three months later. A single blood sample for ADMA was collected from age and sex matched healthy controls (n=40, 2 for each case).Results: CRP increased significantly from day 2; 16 (Confidence interval (CI) 10-23) mg/L to day 4; 84 (CI 47-120) mg/L, (p<0.01). ADMA increased significantly from day 2; 0.22 (CI 0.17-0.27) µmol/L, to day 7; 0.37 (CI 0.21-0.54) µmol/L, p<0.01. ADMA remained elevated at a three-month follow-up 0.36 (CI 0.31-0.42) µmol/L.ADMA in the first sample from the patients (day 1-3); 0.25 (CI 0.19-0.30) µmol/L, was not different from ADMA in matched healthy controls; 0.25 (CI 0.20-0.31), p>0.05.Conclusion: After SAH, CRP and ADMA in serum increased significantly during the first week and ADMA remained elevated three months later.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Anestesi och intensivvård hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Anesthesiology and Intensive Care hsv//eng
Acute-Phase Reaction
C-Reactive Protein
Subarachnoid Hemorrhage
Intracranial Aneurysm
Arginine/administration & dosage/analogs & derivatives/blood

Added entries (persons, corporate bodies, meetings, titles ...)

Olivecrona, MagnusUmeå universitet,Klinisk neurovetenskap(Swepub:umu)masola78 (author)
Koskinen, Lars-OweUmeå universitet,Klinisk neurovetenskap(Swepub:umu)lako0002 (author)
Naredi, SilvanaUmeå universitet,Anestesiologi och intensivvård(Swepub:umu)nasi0001 (author)
Hultin, MagnusUmeå universitet,Anestesiologi och intensivvård(Swepub:umu)mahu0016 (author)
Umeå universitetAnestesiologi och intensivvård (creator_code:org_t)

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In:Scandinavian Journal of Clinical and Laboratory Investigation: Informa UK Limited72:6, s. 484-4890036-55131502-7686

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