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  • Ekelund, U. (author)

Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women : the EPIC-InterAct Study

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • 2012-04-21
  • Springer Science and Business Media LLC,2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-57138
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-57138URI
  • https://doi.org/10.1007/s00125-012-2532-2DOI
  • https://lup.lub.lu.se/record/2891069URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Group author: InterAct Consortium
  • We examined the independent and combined associations of physical activity and obesity with incident type 2 diabetes in men and women. The InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a randomly selected subcohort of 16,154 individuals, drawn from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Physical activity was assessed by a four-category index. Obesity was measured by BMI and waist circumference (WC). Associations between physical activity, obesity and case-ascertained incident type 2 diabetes were analysed by Cox regression after adjusting for educational level, smoking status, alcohol consumption and energy intake. In combined analyses, individuals were stratified according to physical activity level, BMI and WC. A one-category difference in physical activity (equivalent to approximately 460 and 365 kJ/day in men and women, respectively) was independently associated with a 13% (HR 0.87, 95% CI 0.80, 0.94) and 7% (HR 0.93, 95% CI 0.89, 0.98) relative reduction in the risk of type 2 diabetes in men and women, respectively. Lower levels of physical activity were associated with an increased risk of diabetes across all strata of BMI. Comparing inactive with active individuals, the HRs were 1.44 (95% CI 1.11, 1.87) and 1.38 (95% CI 1.17, 1.62) in abdominally lean and obese inactive men, respectively, and 1.57 (95% CI 1.19, 2.07) and 1.19 (95% CI 1.01, 1.39) in abdominally lean and obese inactive women, respectively. Physical activity is associated with a reduction in the risk of developing type 2 diabetes across BMI categories in men and women, as well as in abdominally lean and obese men and women.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Palla, L. (author)
  • Brage, S. (author)
  • Franks, Paul W.Lunds universitet,Umeå universitet,Medicin,Lund University, Malmö, Sweden,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology(Swepub:lu)med-plf (author)
  • Peters, T. (author)
  • Balkau, B. (author)
  • Diaz, M. J. T. (author)
  • Huerta, J. M. (author)
  • Agnoli, C. (author)
  • Arriola, L. (author)
  • Ardanaz, E. (author)
  • Boeing, H. (author)
  • Clavel-Chapelon, F. (author)
  • Crowe, F. (author)
  • Fagherazzi, G. (author)
  • Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
  • Hainaut, P. (author)
  • Johnsen, N. Fons (author)
  • Kaaks, R. (author)
  • Khaw, K. T. (author)
  • Key, T. J. (author)
  • de Lauzon-Guillain, B. (author)
  • May, A. (author)
  • Monninkhof, E. (author)
  • Navarro, C. (author)
  • Nilsson, PeterLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (author)
  • Ostergaard, J. Nautrup (author)
  • Norat, T. (author)
  • Overvad, K. (author)
  • Palli, D. (author)
  • Panico, S. (author)
  • Redondo, M. L. (author)
  • Ricceri, F. (author)
  • Rolandsson, OlovUmeå universitet,Allmänmedicin(Swepub:umu)olro0005 (author)
  • Romaguera, D. (author)
  • Romieu, I. (author)
  • Sanchez Perez, M. J. (author)
  • Slimani, N. (author)
  • Spijkerman, A. (author)
  • Teucher, B. (author)
  • Tjonneland, A. (author)
  • Travier, N. (author)
  • Tumino, R. (author)
  • Vos, W. (author)
  • Vigl, M. (author)
  • Sharp, S. (author)
  • Langenberg, C. (author)
  • Forouhi, N. (author)
  • Riboli, E. (author)
  • Feskens, E. (author)
  • Wareham, N. J. (author)
  • Umeå universitetMedicin (creator_code:org_t)

Related titles

  • In:Diabetologia: Springer Science and Business Media LLC55:7, s. 1944-19520012-186X1432-0428

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