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Adiposity, hormone ...
Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status : a large prospective cohort study.
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Ritte, Rebecca (author)
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Lukanova, Annekatrin (author)
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Berrino, Franco (author)
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Dossus, Laure (author)
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Tjønneland, Anne (author)
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Olsen, Anja (author)
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Overvad, Thure Filskov (author)
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Overvad, Kim (author)
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Clavel-Chapelon, Françoise (author)
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Fournier, Agnès (author)
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Fagherazzi, Guy (author)
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Rohrmann, Sabine (author)
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Teucher, Birgit (author)
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Boeing, Heiner (author)
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Aleksandrova, Krasimira (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Palli, Domenico (author)
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Sieri, Sabina (author)
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Panico, Salvatore (author)
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Tumino, Rosario (author)
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Vineis, Paolo (author)
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Quirós, José Ramón (author)
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Buckland, Genevieve (author)
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Sánchez, Maria-José (author)
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Amiano, Pilar (author)
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Chirlaque, María-Dolores (author)
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Ardanaz, Eva (author)
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- Sund, Malin, 1972- (author)
- Umeå universitet,Kirurgi,Malin Sund
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- Lenner, Per (author)
- Umeå universitet,Onkologi
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Bueno-de-Mesquita, Bas (author)
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van Gils, Carla H (author)
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Peeters, Petra Hm (author)
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Krum-Hansen, Sanda (author)
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Gram, Inger Torhild (author)
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Lund, Eiliv (author)
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Allen, Naomi E (author)
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Key, Timothy J (author)
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Romieu, Isabelle (author)
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Rinaldi, Sabina (author)
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Siddiq, Afshan (author)
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Cox, David (author)
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Riboli, Elio (author)
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Kaaks, Rudolf (author)
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(creator_code:org_t)
- 2012-05-14
- 2012
- English.
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In: Breast cancer research : BCR. - London : BioMed Central. - 1465-542X. ; 14:3, s. R76-
- Related links:
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https://umu.diva-por... (primary) (Raw object)
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https://breast-cance...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- ABSTRACT: INTRODUCTION: Associations of hormone-receptor positive breast cancer with excess adiposity are reasonably well characterized; however, uncertainty remains regarding the association of body mass index (BMI) with hormone-receptor negative malignancies, and possible interactions by hormone replacement therapy (HRT) use. METHODS: Within the European EPIC cohort, Cox proportional hazards models were used to describe the relationship of BMI, waist and hip circumferences with risk of estrogen-receptor (ER) negative and progesterone-receptor (PR) negative (n = 1,021) and ER+PR+ (n = 3,586) breast tumors within five-year age bands. Among postmenopausal women, the joint effects of BMI and HRT use were analyzed. RESULTS: For risk of ER-PR- tumors, there was no association of BMI across the age bands. However, when analyses were restricted to postmenopausal HRT never users, a positive risk association with BMI (third versus first tertile HR = 1.47 (1.01 to 2.15)) was observed. BMI was inversely associated with ER+PR+ tumors among women aged ≤49 years (per 5 kg/m2 increase, HR = 0.79 (95%CI 0.68 to 0.91)), and positively associated with risk among women ≥65 years (HR = 1.25 (1.16 to 1.34)). Adjusting for BMI, waist and hip circumferences showed no further associations with risks of breast cancer subtypes. Current use of HRT was significantly associated with an increased risk of receptor-negative (HRT current use compared to HRT never use HR: 1.30 (1.05 to 1.62)) and positive tumors (HR: 1.74 (1.56 to 1.95)), although this risk increase was weaker for ER-PR- disease (Phet = 0.035). The association of HRT was significantly stronger in the leaner women (BMI ≤22.5 kg/m2) than for more overweight women (BMI ≥25.9 kg/m2) for, both, ER-PR- (HR: 1.74 (1.15 to 2.63)) and ER+PR+ (HR: 2.33 (1.84 to 2.92)) breast cancer and was not restricted to any particular HRT regime. CONCLUSIONS: An elevated BMI may be positively associated with risk of ER-PR- tumors among postmenopausal women who never used HRT. Furthermore, postmenopausal HRT users were at an increased risk of ER-PR- as well as ER+PR+ tumors, especially among leaner women. For hormone-receptor positive tumors, but not for hormone-receptor negative tumors, our study confirms an inverse association of risk with BMI among young women of premenopausal age. Our data provide evidence for a possible role of sex hormones in the etiology of hormone-receptor negative tumors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- body-mass index
- estrogen-receptor
- united-states
- postmenopausal women
- premenopausal omen
- physical-activity
- fat distribution
- nutrition
- size
- weight
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ritte, Rebecca
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Lukanova, Anneka ...
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Berrino, Franco
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Dossus, Laure
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Tjønneland, Anne
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Olsen, Anja
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Overvad, Thure F ...
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Overvad, Kim
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Clavel-Chapelon, ...
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Fournier, Agnès
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Fagherazzi, Guy
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Rohrmann, Sabine
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Teucher, Birgit
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Boeing, Heiner
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Aleksandrova, Kr ...
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Trichopoulou, An ...
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Lagiou, Pagona
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Trichopoulos, Di ...
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Palli, Domenico
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Sieri, Sabina
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Panico, Salvator ...
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Tumino, Rosario
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Vineis, Paolo
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Quirós, José Ram ...
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Buckland, Genevi ...
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Sánchez, Maria-J ...
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Amiano, Pilar
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Chirlaque, María ...
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Ardanaz, Eva
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Sund, Malin, 197 ...
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Lenner, Per
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Bueno-de-Mesquit ...
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van Gils, Carla ...
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Peeters, Petra H ...
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Krum-Hansen, San ...
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Gram, Inger Torh ...
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Lund, Eiliv
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Khaw, Kay-Tee
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Wareham, Nick
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Allen, Naomi E
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Key, Timothy J
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Romieu, Isabelle
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Rinaldi, Sabina
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Siddiq, Afshan
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Cox, David
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Riboli, Elio
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Kaaks, Rudolf
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Breast cancer re ...
- By the university
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Umeå University