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WNT16 influences bo...
WNT16 influences bone mineral density, Cortical bone thickness, bone strength, and Osteoporotic fracture risk
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Zheng, Hou-Feng (author)
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Tobias, Jon H (author)
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Duncan, Emma (author)
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show more...
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Evans, David M (author)
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- Eriksson, Joel (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Paternoster, Lavinia (author)
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Yerges-Armstrong, Laura M (author)
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Lehtimäki, Terho (author)
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- Bergström, Ulrica (author)
- Umeå universitet,Institutionen för kirurgisk och perioperativ vetenskap
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Kähönen, Mika (author)
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Leo, Paul J (author)
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Raitakari, Olli (author)
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Laaksonen, Marika (author)
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Nicholson, Geoffrey C (author)
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Viikari, Jorma (author)
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Ladouceur, Martin (author)
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Lyytikäinen, Leo-Pekka (author)
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Medina-Gomez, Carolina (author)
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Rivadeneira, Fernando (author)
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Prince, Richard L (author)
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Sievanen, Harri (author)
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Leslie, William D (author)
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- Mellström, Dan, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Eisman, John A (author)
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- Movérare-Skrtic, Sofia (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Goltzman, David (author)
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Hanley, David A (author)
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Jones, Graeme (author)
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St Pourcain, Beate (author)
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Xiao, Yongjun (author)
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Timpson, Nicholas J (author)
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Smith, George Davey (author)
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Reid, Ian R (author)
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Ring, Susan M (author)
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Sambrook, Philip N (author)
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- Karlsson, Magnus (author)
- Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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Dennison, Elaine M (author)
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Kemp, John P (author)
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Danoy, Patrick (author)
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Sayers, Adrian (author)
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Wilson, Scott G (author)
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- Nethander, Maria, 1980 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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McCloskey, Eugene (author)
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- Vandenput, Liesbeth, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Eastell, Richard (author)
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Liu, Jeff (author)
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Spector, Tim (author)
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Mitchell, Braxton D (author)
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Streeten, Elizabeth A (author)
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Brommage, Robert (author)
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- Pettersson-Kymmer, Ulrika (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Farmakologi
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Brown, Matthew A (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Richards, J Brent (author)
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- Lorentzon, Mattias, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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(creator_code:org_t)
- 2012-07-05
- 2012
- English.
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In: PLoS genetics. - SAN FRANCISCO, USA : PUBLIC LIBRARY SCIENCE. - 1553-7404. ; 8:7, s. e1002745-
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and for BMD in 5 cohorts comprising 5,672 individuals. We then assessed selected single-nucleotide polymorphisms (SNPs) for osteoporotic fracture in 2,023 cases and 3,740 controls. Association with CBT and forearm BMD was tested for ∼2.5 million SNPs in each cohort separately, and results were meta-analyzed using fixed effect meta-analysis. We identified a missense SNP (Thr>Ile; rs2707466) located in the WNT16 gene (7q31), associated with CBT (effect size of -0.11 standard deviations [SD] per C allele, P = 6.2×10(-9)). This SNP, as well as another nonsynonymous SNP rs2908004 (Gly>Arg), also had genome-wide significant association with forearm BMD (-0.14 SD per C allele, P = 2.3×10(-12), and -0.16 SD per G allele, P = 1.2×10(-15), respectively). Four genome-wide significant SNPs arising from BMD meta-analysis were tested for association with forearm fracture. SNP rs7776725 in FAM3C, a gene adjacent to WNT16, was associated with a genome-wide significant increased risk of forearm fracture (OR = 1.33, P = 7.3×10(-9)), with genome-wide suggestive signals from the two missense variants in WNT16 (rs2908004: OR = 1.22, P = 4.9×10(-6) and rs2707466: OR = 1.22, P = 7.2×10(-6)). We next generated a homozygous mouse with targeted disruption of Wnt16. Female Wnt16(-/-) mice had 27% (P<0.001) thinner cortical bones at the femur midshaft, and bone strength measures were reduced between 43%-61% (6.5×10(-13)
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- genetik
- Genetics
- Orthopaedics
- ortopedi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Zheng, Hou-Feng
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Tobias, Jon H
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Duncan, Emma
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Evans, David M
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Eriksson, Joel
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Paternoster, Lav ...
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show more...
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Yerges-Armstrong ...
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Lehtimäki, Terho
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Bergström, Ulric ...
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Kähönen, Mika
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Leo, Paul J
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Raitakari, Olli
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Laaksonen, Marik ...
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Nicholson, Geoff ...
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Viikari, Jorma
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Ladouceur, Marti ...
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Lyytikäinen, Leo ...
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Medina-Gomez, Ca ...
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Rivadeneira, Fer ...
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Prince, Richard ...
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Sievanen, Harri
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Leslie, William ...
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Mellström, Dan, ...
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Eisman, John A
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Movérare-Skrtic, ...
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Goltzman, David
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Hanley, David A
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Jones, Graeme
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St Pourcain, Bea ...
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Xiao, Yongjun
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Timpson, Nichola ...
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Smith, George Da ...
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Reid, Ian R
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Ring, Susan M
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Sambrook, Philip ...
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Karlsson, Magnus
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Dennison, Elaine ...
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Kemp, John P
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Danoy, Patrick
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Sayers, Adrian
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Wilson, Scott G
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Nethander, Maria ...
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McCloskey, Eugen ...
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Vandenput, Liesb ...
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Eastell, Richard
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Liu, Jeff
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Spector, Tim
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Mitchell, Braxto ...
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Streeten, Elizab ...
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Brommage, Robert
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Pettersson-Kymme ...
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Brown, Matthew A
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Ohlsson, Claes, ...
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Richards, J Bren ...
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Lorentzon, Matti ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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PLoS genetics
- By the university
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Umeå University
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Lund University
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University of Gothenburg