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Lowering apolipopro...
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Holmberg, Rebecka
(författare)
Lowering apolipoprotein CIII delays onset of type 1 diabetes
- Artikel/kapitelEngelska2011
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2011-06-13
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National Academy of Sciences,2011
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LIBRIS-ID:oai:DiVA.org:umu-57947
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-57947URI
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https://doi.org/10.1073/pnas.1019553108DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:122831740URI
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Språk:engelska
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Sammanfattning på:engelska
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Serum levels of apolipoprotein CIII (apoCIII) are increased in type 1 diabetic patients, and when β cells are exposed to these diabetic sera, apoptosis occurs, an effect abolished by an antibody against apoCIII. We have investigated the BB rat, an animal model that develops a human-like type 1 diabetes, and found that apoCIII was also increased in sera from prediabetic rats. This increase in apoCIII promoted β-cell death. The endogenous levels of apoCIII were reduced by treating prediabetic animals with an antisense against this apolipoprotein, resulting in a significantly delayed onset of diabetes. ApoCIII thus serves as a diabetogenic factor, and intervention with this apolipoprotein in the prediabetic state can arrest disease progression. These findings suggest apoCIII as a target for the treatment of type 1 diabetes.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Refai, EssamKarolinska Institutet
(författare)
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Höög, AndersKarolinska Institutet
(författare)
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Crooke, Rosanne M
(författare)
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Graham, Mark
(författare)
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Olivecrona, GunillaUmeå universitet,Fysiologisk kemi(Swepub:umu)guol0002
(författare)
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Berggren, Per-OlofKarolinska Institutet
(författare)
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Juntti-Berggren, LisaKarolinska Institutet
(författare)
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Karolinska InstitutetFysiologisk kemi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Proceedings of the National Academy of Sciences of the United States of America: National Academy of Sciences108:26, s. 10685-106890027-84241091-6490
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