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Anterograde Jelly b...
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Bazigou, Eleni
(författare)
Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila.
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-5859
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-5859URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Anaplastic lymphoma kinase (Alk) has been proposed to regulate neuronal development based on its expression pattern in vertebrates and invertebrates; however, its function in vivo is unknown. We demonstrate that Alk and its ligand Jelly belly (Jeb) play a central role as an anterograde signaling pathway mediating neuronal circuit assembly in the Drosophila visual system. Alk is expressed and required in target neurons in the optic lobe, whereas Jeb is primarily generated by photoreceptor axons and functions in the eye to control target selection of R1-R6 axons in the lamina and R8 axons in the medulla. Impaired Jeb/Alk function affects layer-specific expression of three cell-adhesion molecules, Dumbfounded/Kirre, Roughest/IrreC, and Flamingo, in the medulla. Moreover, loss of flamingo in target neurons causes some R8-axon targeting errors observed in Jeb and Alk mosaic animals. Together, these findings suggest that Jeb/Alk signaling helps R-cell axons to shape their environment for target recognition.
Ämnesord och genrebeteckningar
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Animals
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Animals; Genetically Modified
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Axons/*metabolism
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Cadherins/metabolism
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Cell Adhesion Molecules; Neuronal/metabolism
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Drosophila Proteins/*metabolism
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Drosophila melanogaster/growth & development/*metabolism
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Eye/growth & development/innervation
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Eye Proteins/metabolism
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Female
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Larva/growth & development
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Male
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Membrane Proteins/metabolism
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Muscle Proteins/metabolism
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Optic Lobe/growth & development
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Photoreceptors; Invertebrate/cytology/metabolism
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Protein-Tyrosine Kinases/genetics/*metabolism
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Pupa/growth & development
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Retina/cytology/growth & development/metabolism
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Signal Transduction
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Apitz, Holger
(författare)
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Johansson, JanaUmeå universitet,Umeå centrum för molekylär patogenes (UCMP) (Medicinska fakulteten)
(författare)
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Lorén, ChristinaUmeå universitet,Umeå centrum för molekylär patogenes (UCMP) (Medicinska fakulteten)
(författare)
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Hirst, Elizabeth M A
(författare)
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Chen, Pei-Ling
(författare)
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Palmer, RuthUmeå universitet,Umeå centrum för molekylär patogenes (UCMP) (Medicinska fakulteten)(Swepub:umu)rupa0001
(författare)
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Salecker, Iris
(författare)
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Umeå universitetUmeå centrum för molekylär patogenes (UCMP) (Medicinska fakulteten)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cell128:5, s. 961-750092-8674
Internetlänk
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Cell
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