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Pathway analysis of...
Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer
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Li, Donghui (author)
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Duell, Eric J. (author)
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Yu, Kai (author)
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show more...
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Risch, Harvey A. (author)
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Olson, Sara H. (author)
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Kooperberg, Charles (author)
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Wolpin, Brian M. (author)
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Jiao, Li (author)
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Dong, Xiaoqun (author)
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Wheeler, Bill (author)
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Arslan, Alan A. (author)
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Bueno-de-Mesquita, H. Bas (author)
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Fuchs, Charles S. (author)
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Gallinger, Steven (author)
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Gross, Myron (author)
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Hartge, Patricia (author)
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Hoover, Robert N. (author)
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Holly, Elizabeth A. (author)
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Jacobs, Eric J. (author)
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Klein, Alison P. (author)
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LaCroix, Andrea (author)
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Mandelson, Margaret T. (author)
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Petersen, Gloria (author)
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Zheng, Wei (author)
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Agalliu, Ilir (author)
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Albanes, Demetrius (author)
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Boutron-Ruault, Marie-Christine (author)
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Bracci, Paige M. (author)
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Buring, Julie E. (author)
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Canzian, Federico (author)
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Chang, Kenneth (author)
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Chanock, Stephen J. (author)
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Cotterchio, Michelle (author)
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Gaziano, J. Michael (author)
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Giovannucci, Edward L. (author)
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Goggins, Michael (author)
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- Hallmans, Göran, 1947- (author)
- Umeå universitet,Näringsforskning
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Hankinson, Susan E. (author)
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Bolton, Judith A. Hoffman (author)
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Hunter, David J. (author)
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Hutchinson, Amy (author)
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Jacobs, Kevin B. (author)
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Jenab, Mazda (author)
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Khaw, Kay-Tee (author)
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Kraft, Peter (author)
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Krogh, Vittorio (author)
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Kurtz, Robert C. (author)
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McWilliams, Robert R. (author)
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Mendelsohn, Julie B. (author)
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Patel, Alpa V. (author)
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Rabe, Kari G. (author)
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Riboli, Elio (author)
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Shu, Xiao-Ou (author)
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Tjonneland, Anne (author)
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Tobias, Geoffrey S. (author)
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Trichopoulos, Dimitrios (author)
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Virtamo, Jarmo (author)
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Visvanathan, Kala (author)
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Watters, Joanne (author)
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Yu, Herbert (author)
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Zeleniuch-Jacquotte, Anne (author)
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Amundadottir, Laufey (author)
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Stolzenberg-Solomon, Rachael Z. (author)
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(creator_code:org_t)
- 2012-04-20
- 2012
- English.
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In: Carcinogenesis. - : Oxford University Press. - 0143-3334 .- 1460-2180. ; 33:7, s. 1384-1390
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Four loci have been associated with pancreatic cancer through genome-wide association studies (GWAS). Pathway-based analysis of GWAS data is a complementary approach to identify groups of genes or biological pathways enriched with disease-associated single-nucleotide polymorphisms (SNPs) whose individual effect sizes may be too small to be detected by standard single-locus methods. We used the adaptive rank truncated product method in a pathway-based analysis of GWAS data from 3851 pancreatic cancer cases and 3934 control participants pooled from 12 cohort studies and 8 case-control studies (PanScan). We compiled 23 biological pathways hypothesized to be relevant to pancreatic cancer and observed a nominal association between pancreatic cancer and five pathways (P < 0.05), i.e. pancreatic development, Helicobacter pylori lacto/neolacto, hedgehog, Th1/Th2 immune response and apoptosis (P = 2.0 x 10(-6), 1.6 x 10(-5), 0.0019, 0.019 and 0.023, respectively). After excluding previously identified genes from the original GWAS in three pathways (NR5A2, ABO and SHH), the pancreatic development pathway remained significant (P = 8.3 x 10(-5)), whereas the others did not. The most significant genes (P < 0.01) in the five pathways were NR5A2, HNF1A, HNF4G and PDX1 for pancreatic development; ABO for H.pylori lacto/neolacto; SHH for hedgehog; TGFBR2 and CCL18 for Th1/Th2 immune response and MAPK8 and BCL2L11 for apoptosis. Our results provide a link between inherited variation in genes important for pancreatic development and cancer and show that pathway-based approaches to analysis of GWAS data can yield important insights into the collective role of genetic risk variants in cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Li, Donghui
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Duell, Eric J.
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Yu, Kai
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Risch, Harvey A.
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Olson, Sara H.
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Kooperberg, Char ...
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show more...
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Wolpin, Brian M.
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Jiao, Li
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Dong, Xiaoqun
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Wheeler, Bill
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Arslan, Alan A.
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Bueno-de-Mesquit ...
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Fuchs, Charles S ...
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Gallinger, Steve ...
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Gross, Myron
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Hartge, Patricia
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Hoover, Robert N ...
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Holly, Elizabeth ...
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Jacobs, Eric J.
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Klein, Alison P.
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LaCroix, Andrea
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Mandelson, Marga ...
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Petersen, Gloria
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Zheng, Wei
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Agalliu, Ilir
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Albanes, Demetri ...
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Boutron-Ruault, ...
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Bracci, Paige M.
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Buring, Julie E.
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Canzian, Federic ...
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Chang, Kenneth
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Chanock, Stephen ...
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Cotterchio, Mich ...
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Gaziano, J. Mich ...
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Giovannucci, Edw ...
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Goggins, Michael
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Hallmans, Göran, ...
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Hankinson, Susan ...
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Bolton, Judith A ...
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Hunter, David J.
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Hutchinson, Amy
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Jacobs, Kevin B.
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Jenab, Mazda
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Khaw, Kay-Tee
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Kraft, Peter
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Krogh, Vittorio
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Kurtz, Robert C.
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McWilliams, Robe ...
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Mendelsohn, Juli ...
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Patel, Alpa V.
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Rabe, Kari G.
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Riboli, Elio
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Shu, Xiao-Ou
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Tjonneland, Anne
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Tobias, Geoffrey ...
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Trichopoulos, Di ...
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Virtamo, Jarmo
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Visvanathan, Kal ...
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Watters, Joanne
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Yu, Herbert
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Zeleniuch-Jacquo ...
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Amundadottir, La ...
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Stolzenberg-Solo ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Carcinogenesis
- By the university
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Umeå University