Specification of dorsal telencephalic character by sequential Wnt and FGF signaling.

• Dorsoventral patterning of the telencephalon is established early in forebrain development and underlies many of the regional subdivisions that are critical to the later organization of neural circuits in the cerebral cortex and basal ganglia. Sonic hedgehog (Shh) is involved in the generation of the ventral-most telencephalic cells, but the identity of the extrinsic signal(s) that induce dorsal character in telencephalic cells is not known. Here we show in chick embryos that sequential Wnt and fibroblast growth factor (FGF) signaling specifies cells of dorsal telencephalic character.

Nyckelord

Aging/genetics/metabolism

Animals

Basic Helix-Loop-Helix Transcription Factors

Bone Morphogenetic Proteins/physiology

Cell Differentiation

Chick Embryo

Ectoderm/cytology/physiology

Embryonic Induction/*physiology

Epithelium

Eye Proteins

Fibroblast Growth Factors/classification/genetics/*physiology

Frizzled Receptors

Gene Expression Regulation; Developmental

Homeodomain Proteins/genetics/metabolism

Immunohistochemistry

In Situ Hybridization/methods

Mice

Nerve Tissue Proteins/genetics/metabolism

Organ Culture Techniques

Paired Box Transcription Factors

Proteins/physiology

Proto-Oncogene Proteins/genetics/*physiology

Pyrroles/pharmacology

Receptors; Fibroblast Growth Factor/physiology

Repressor Proteins

Signal Transduction/genetics/*physiology

Stem Cells/metabolism

Telencephalon/cytology/embryology/metabolism/*physiology

Transcription Factors

Wnt Proteins

Zebrafish Proteins

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)