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Differential expres...
Differential expression of interferon genes in a substrain of Namalwa cells.
- Artikel/kapitelEngelska1985
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LIBRIS-ID:oai:DiVA.org:umu-59650
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-59650URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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A substrain of Namalwa cells producing a high ratio of beta-interferon (IFN-beta) versus alpha-interferon (IFN-alpha) was investigated by constructing a cDNA library after induction with Sendai virus. The library was screened by two synthetic oligonucleotides, one specific for IFN-alpha and one complementary to both IFN-alpha and IFN-beta. Rescreening the library with two full-length cDNAs encoding IFN-alpha and IFN-beta, respectively, revealed that the frequency of the IFN-alpha and IFN-beta clones reflected the activities of IFN-alpha and IFN-beta obtained by functional assays. On the cDNA level, the dominating species was identical with the type of IFN-alpha A or IFN-alpha 2; however, one new type of cDNA also was found that was similar to the previously described IFN-alpha C. Only one type of cDNA was found encoding IFN-beta, although several IFN-beta proteins have been detected in the analyzed cell line.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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von Gabain, A
(författare)
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Edlund, T
(författare)
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Ny, TorUmeå universitet,Institutionen för medicinsk kemi och biofysik(Swepub:umu)TONY0001
(författare)
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Lundgren, E
(författare)
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Umeå universitetInstitutionen för medicinsk kemi och biofysik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of interferon research5:2, s. 229-380197-8357
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