Search: WFRF:(Gunnarsson M.) >
Elevated IgA antiph...
Elevated IgA antiphospholipid antibodies in healthy pregnant women in Sudan but not Sweden, without corresponding increase in IgA anti-β2 glycoprotein I domain 1 antibodies
-
- Elbagir, Sahwa (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
- Mohammed, N.A. (author)
- Al Neelain Univ, Fac Med Lab Sci, Khartoum, Sudan
-
- Kaihola, Helena, 1969- (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Helena Åkerud
-
show more...
-
- Svenungsson, E. (author)
- Karolinska Institutet
-
- Gunnarsson, I. (author)
- Karolinska Institutet
-
- Manivel, Vivek Anand (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
- Pertsinidou, Eleftheria (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
- Elagib, E.M. (author)
- Mil Hosp, Rheumatol Unit, Omdurman, Sudan
-
- Nur, M.A.M. (author)
- Alribat Univ Hosp, Rheumatol Unit, Khartoum, Sudan
-
- Elussein, E.A. (author)
- Acad Med Sci & Technol, Khartoum Fertil Ctr, Khartoum, Sudan
-
- ElShafie, Amir Ibrahim, 1970- (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
- Åkerud, Helena, 1972- (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
- Rönnelid, Johan (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
-
show less...
-
(creator_code:org_t)
- 2020-02-27
- 2020
- English.
-
In: Lupus. - : SAGE Publications. - 0961-2033 .- 1477-0962. ; 29:5, s. 463-473
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://journals.sag...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Objective: The role of antiphospholipid antibodies (aPL) during apparently normal pregnancy is still unclear. IgA aPL are prevalent in populations of African origin. Our aim was to measure all isotypes of anticardiolipin (anti-CL) and anti–β2 glycoprotein I (anti-β2GPI) in healthy pregnant and non-pregnant women of different ethnicities.Methods: Healthy Sudanese pregnant women (n = 165; 53 sampled shortly after delivery), 96 age-matched Sudanese female controls and 42 healthy pregnant and 249 non-pregnant Swedish women were included. IgA/G/M anti-CL and anti-β2GPI were tested at one time point only with two independent assays in Sudanese and serially in pregnant Swedes. IgA anti-β2GPI domain 1 and as controls IgA/G/M rheumatoid factor (RF), IgG anti–cyclic citrullinated peptide 2 (anti-CCP2) and anti–thyroid peroxidase (anti-TPO) were investigated in Sudanese females.Results: Pregnant Sudanese women had significantly higher median levels of IgA anti-CL, IgA anti-β2GPI (p < 0.0001 for both antibodies using two assays) and IgM anti-β2GPI (both assays; p < 0.0001 and 0.008) compared with non-pregnant Sudanese. IgA anti-CL and anti-β2GPI occurrence was increased among Sudanese pregnant women compared with national controls. No corresponding increase during pregnancy was found for IgA anti-β2GPI domain 1 antibodies. Both IgG anti-CL and IgG control autoantibodies decreased during and directly after pregnancy among Sudanese. Serially followed Swedish women showed no changes in IgA aPL, whereas IgG/M anti-CL decreased.Conclusions: IgA aPL are increased in Sudanese but not in Swedish women, without corresponding increase in IgA domain 1. Whether due to ethnicity and/or environmental influences the occurrence of IgA aPL during Sudanese pregnancies, and its clinical significance, is yet to be determined.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Africa
- Antiphospholipid antibodies
- IgA
- Sudan
- healthy
- pregnancy
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Lupus
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Elbagir, Sahwa
-
Mohammed, N.A.
-
Kaihola, Helena, ...
-
Svenungsson, E.
-
Gunnarsson, I.
-
Manivel, Vivek A ...
-
show more...
-
Pertsinidou, Ele ...
-
Elagib, E.M.
-
Nur, M.A.M.
-
Elussein, E.A.
-
ElShafie, Amir I ...
-
Åkerud, Helena, ...
-
Rönnelid, Johan
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Lupus
- By the university
-
Uppsala University
-
Karolinska Institutet