SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Armstrong Robert)
 

Search: WFRF:(Armstrong Robert) > A variable age of o...

  • Sun, Xiangqing (author)

A variable age of onset segregation model for linkage analysis, with correction for ascertainment, applied to glioma

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • 2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-60171
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60171URI
  • https://doi.org/10.1158/1055-9965.EPI-12-0703DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: We propose a two-step model-based approach, with correction for ascertainment, to linkage analysis of a binary trait with variable age of onset and apply it to a set of multiplex pedigrees segregating for adult glioma.Methods: First, we fit segregation models by formulating the likelihood for a person to have a bivariate phenotype, affection status and age of onset, along with other covariates, and from these we estimate population trait allele frequencies and penetrance parameters as a function of age (N=281 multiplex glioma pedigrees). Second, the best fitting models are used as trait models in multipoint linkage analysis (N=74 informative multiplex glioma pedigrees). To correct for ascertainment, a prevalence constraint is used in the likelihood of the segregation models for all 281 pedigrees. Then the trait allele frequencies are re-estimated for the pedigree founders of the subset of 74 pedigrees chosen for linkage analysis.Results: Using the best fitting segregation models in model-based multipoint linkage analysis, we identified two separate peaks on chromosome 17; the first agreed with a region identified by Shete et al. (1) who used model-free affected-only linkage analysis, but with a narrowed peak: and the second agreed with a second region they found but had a larger maximum LOD.Conclusions/Impact: Our approach has the advantage of not requiring markers to be in linkage equilibrium unless the minor allele frequency is small (markers which tend to be uninformative for linkage), and of using more of the available information for LOD-based linkage analysis.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Vengoechea, Jaime (author)
  • Elston, Robert (author)
  • Chen, Yanwen (author)
  • Amos, Christopher I (author)
  • Armstrong, Georgina (author)
  • Bernstein, Jonine L (author)
  • Claus, Elizabeth B (author)
  • Davis, Faith (author)
  • Houlston, Richard S (author)
  • Il'yasova, Dora (author)
  • Jenkins, Robert B (author)
  • Johansen, Christoffer (author)
  • Lai, Rose (author)
  • Lau, Ching (author)
  • Liu, Yanhong (author)
  • McCarthy, Bridget J (author)
  • Olson, Sara H (author)
  • Sadetzki, Siegal (author)
  • Schildkraut, Joellen M (author)
  • Shete, Sanjay S (author)
  • Yu, Robert (author)
  • Vick, Nicholas A (author)
  • Merrell, Ryan (author)
  • Wrensch, Margaret R (author)
  • Yang, Ping (author)
  • Melin, BeatriceUmeå universitet,Onkologi(Swepub:umu)bema0010 (author)
  • Bondy, Melissa L (author)
  • Barnholtz-Sloan, Jill S (author)
  • Umeå universitetOnkologi (creator_code:org_t)

Related titles

  • In:Cancer Epidemiology, Biomarkers and Prevention21:12, s. 2242-22511055-99651538-7755

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view