Sökning: L773:0363 6127 OR L773:1522 1466 OR L773:1931 857X >
Reduced kidney lipo...
Reduced kidney lipoprotein lipase and renal tubule triglyceride accumulation in cisplatin-mediated acute kidney injury
-
Li, Shenyang (författare)
-
Nagothu, Kiran (författare)
-
Ranganathan, Gouri (författare)
-
visa fler...
-
Ali, Syed M. (författare)
-
Shank, Brian (författare)
-
Gokden, Neriman (författare)
-
Ayyadevara, Srinivas (författare)
-
Megyesi, Judit (författare)
-
- Olivecrona, Gunilla (författare)
- Umeå universitet,Fysiologisk kemi
-
Chugh, Sumant S. (författare)
-
Kersten, Sander (författare)
-
Portilla, Didier (författare)
-
visa färre...
-
(creator_code:org_t)
- American Physiological Society, 2012
- 2012
- Engelska.
-
Ingår i: American Journal of Physiology - Renal Physiology. - : American Physiological Society. - 0363-6127 .- 1522-1466 .- 1931-857X. ; 303:3, s. F437-F448
- Relaterad länk:
-
https://europepmc.or...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Peroxisome proliferator-activated receptor-alpha (PPAR alpha) activation attenuates cisplatin (CP)-mediated acute kidney injury by increasing fatty acid oxidation, but mechanisms leading to reduced renal triglyceride (TG) accumulation could also contribute. Here, we investigated the effects of PPAR alpha and CP on expression and enzyme activity of kidney lipoprotein lipase (LPL) as well as on expression of angiopoietin protein-like 4 (Angptl4), glycosylphosphatidylinositol-anchored-HDL-binding protein (GPIHBP1), and lipase maturation factor 1 (Lmf1), which are recognized as important proteins that modulate LPL activity. CP caused a 40% reduction in epididymal white adipose tissue (WAT) mass, with a reduction of LPL expression and activity. CP also reduced kidney LPL expression and activity. Angptl4 mRNA levels were increased by ninefold in liver and kidney tissue and by twofold in adipose tissue of CP-treated mice. Western blots of two-dimensional gel electrophoresis identified increased expression of a neutral pI Angptl4 protein in kidney tissue of CP-treated mice. Immunolocalization studies showed reduced staining of LPL and increased staining of Angptl4 primarily in proximal tubules of CP-treated mice. CP also increased TG accumulation in kidney tissue, which was ameliorated by PPAR alpha ligand. In summary, a PPAR alpha ligand ameliorates CP-mediated nephrotoxicity by increasing LPL activity via increased expression of GPHBP1 and Lmf1 and by reducing expression of Angptl4 protein in the proximal tubule.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- peroxisome proliferator-activated receptor
- angiopoietin-like protein 4
- lipase maturation factor 1
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Li, Shenyang
-
Nagothu, Kiran
-
Ranganathan, Gou ...
-
Ali, Syed M.
-
Shank, Brian
-
Gokden, Neriman
-
visa fler...
-
Ayyadevara, Srin ...
-
Megyesi, Judit
-
Olivecrona, Guni ...
-
Chugh, Sumant S.
-
Kersten, Sander
-
Portilla, Didier
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Cell och molekyl ...
- Artiklar i publikationen
-
American Journal ...
- Av lärosätet
-
Umeå universitet