Impact of probiotic feeding during weaning on the serum lipid profile and plasma metabolome in infants

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Chorell, ElinUmeå universitet,Medicin (författare)

Impact of probiotic feeding during weaning on the serum lipid profile and plasma metabolome in infants

Artikel/kapitelEngelska2013

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Cambridge University Press,2013
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LIBRIS-ID:oai:DiVA.org:umu-62208
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-62208URI
https://doi.org/10.1017/S0007114512004618DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

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The gut microbiome interacts with the host in the metabolic response to diet, and early microbial aberrancies may be linked to the development of obesity and metabolic disorders later in life. Probiotics have been proposed to affect metabolic programming and blood lipid levels, although studies are lacking in infants. Here, we report on the lipid profile and global metabolic response following daily feeding of probiotics during weaning. A total of 179 healthy, term infants were randomised to daily intake of cereals with (n 89) or without (n 90) the addition of Lactobacillus paracasei ssp. paracasei F19 (LF19) 108 colony-forming units per serving from 4 to 13 months of age. Weight, length and skinfold thickness were monitored. Venous blood was drawn at 5·5 and 13 months of age for analysis of the serum lipid profile. In a subsample, randomly selected from each group, GC-time-of-flight/MS was used to metabolically characterise plasma samples from thirty-seven infants. A combination of multi- and univariate analysis was applied to reveal differences related to LF19 treatment based on 228 putative metabolites, of which ninety-nine were identified or classified. We observed no effects of probiotic feeding on anthropometrics or the serum lipid profile. However, we detected significantly lower levels of palmitoleic acid (16 : 1) (P < 0·05) and significantly higher levels of putrescine (P < 0·01) in LF19-treated infants. Palmitoleic acid is a major MUFA strongly linked to visceral obesity, while putrescine is a polyamine with importance for gut integrity. Whether the observed differences will have long-term health consequences are being followed.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
Probiotics
Lactobacillus paracaseissp.paracasei strain F19
Metabolomics
Infant feeding

Biuppslag (personer, institutioner, konferenser, titlar ...)

Videhult, Frida KarlssonUmeå universitet,Pediatrik(Swepub:umu)frakan01 (författare)
Hernell, OlleUmeå universitet,Pediatrik(Swepub:umu)olhe0002 (författare)
Antti, HenrikUmeå universitet,Kemiska institutionen(Swepub:umu)hean0004 (författare)
West, Christina EUmeå universitet,Pediatrik(Swepub:umu)chwe0024 (författare)
Umeå universitetMedicin (creator_code:org_t)

Sammanhörande titlar

Ingår i:British Journal of Nutrition: Cambridge University Press110:1, s. 116-1260007-11451475-2662

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Av författaren/redakt...: Chorell, Elin; Videhult, Frida ...; Hernell, Olle; Antti, Henrik; West, Christina ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Pediatrik

Artiklar i publikationen: British Journal ...

Av lärosätet: Umeå universitet

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