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Epstein-Barr virus ...
Epstein-Barr virus antibodies and vitamin D in prospective multiple sclerosis biobank sampels
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- Salzer, Jonatan, 1981- (författare)
- Umeå universitet,Klinisk neurovetenskap
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- Nyström, Maria (författare)
- Umeå universitet,Klinisk neurovetenskap
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- Hallmans, Göran, 1947- (författare)
- Umeå universitet,Näringsforskning,Enheten för biobanksforskning
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- Stenlund, Hans (författare)
- Umeå universitet,Epidemiologi och global hälsa
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- Wadell, Göran (författare)
- Umeå universitet,Virologi
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- Sundström, Peter (författare)
- Umeå universitet,Klinisk neurovetenskap
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(creator_code:org_t)
- 2013-04-02
- 2013
- Engelska.
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Ingår i: Multiple Sclerosis Journal. - : Sage Publications. - 1352-4585 .- 1477-0970. ; 19:12, s. 1587-1591
- Relaterad länk:
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Increased antibody reactivity against Epstein-Barr Nuclear Antigen-1 (EBNA-1) has been associated with an increased risk for MS, and high levels of 25-Hydroxyvitamin D (25[OH]D) have been associated with a lower risk for MS. Interaction between these two factors has been proposed.Objectives: To examine the association between antibody reactivity against EBNA-1 and five EBNA-1 domains, and the risk for multiple sclerosis (MS), and to examine if these antibodies and 25(OH)D status interact regarding MS risk in prospectively collected blood samples.Methods: Antibody reactivity (as specified above) and 25(OH)D levels were measured using ELISAs in n=192 MS cases and n=384 matched controls. The risk for MS was analysed using matched logistic regression.Results: The risk for MS increased across tertiles of antibody reactivity against EBNA-1, domain EBNA-1402–502, and domain EBNA-1385–420; p trend <0.001. The risk increase was most pronounced for EBNA-1385–420. In young individuals (below median age at sampling, <26.4 years) these associations were stronger, and 25(OH)D levels correlated inversely to antibody reactivity against EBNA-1 and the EBNA-1 domains.Conclusions: We confirm that increased antibody reactivity against EBNA-1 is a risk factor for MS. Our findings in young individuals suggest that 25(OH)D status might influence the immune response towards Epstein-Barr virus, and thereby modulate MS risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Multiple sclerosis
- Case control study
- Risk factors in epidemiology
- Epstein-Barr virus (EBV)
- Epstein-Barr Nuclear Antigen-1 (EBNA-1)
- Vitamin D (25[OH]D)
- Epidemiology
- epidemiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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