WFRF:(Jansson Jan Håkan)
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- Hernestål-Boman, JennyUmeå universitet,Medicin (författare)
Signs of dysregulated fibrinolysis precede the development of type 2 diabetes mellitus in a population-based study
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
- 2012-12-18
- BioMed Central,2012
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:umu-64956
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-64956URI
- https://doi.org/10.1186/1475-2840-11-152DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-220695URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
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Anmärkningar
- Background: Diabetic patients experience stimulated coagulation and dysfibrinolysis, which is associated with an increased risk of cardiovascular events. This imbalance may precede the manifest diagnosis. We investigated whether elevated antigen levels of tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), the tPA/PAI-1 complex, or von Willebrand Factor (VWF) precede type 2 diabetes mellitus (T2DM) diagnosis, and whether this elevation occurs before increased fasting plasma glucose (FPG) or 2-hour plasma glucose (2hPG) in individuals who later develop T2DM.Methods: We conducted a prospective incident case-referent study within the Vasterbotten Intervention Programme. Cardiovascular risk factor data as well as FPG and 2hPG and blood samples for future research were collected at a baseline health examination between 1989 and 2000, (n= 28 736). During follow-up in January 2001, 157 cases had developed T2DM. Referents without T2DM were matched for sex, age, and year of participation (n=277). Subgroup analysis was performed for cases with normal baseline glucose levels (FPG <6.1 mmol/L and 2hPG < 8.9 mmol/L) and cases with elevated levels (FPG 6.1-6.9 mmol/L and/or 2hPG 8.9-12.1 mmol/L).Results: After adjusting for BMI, family history of diabetes, physical activity, smoking, systolic blood pressure and levels of C-reactive protein and triglycerides, independent associations were found between incident T2DM and elevated levels of tPA (OR=1.54, 95% CI 1.06-2.23), PAI-1 (OR=1.61, 95% CI 1.14-2.28), and tPA/PAI-1 complex (OR=2.45, 95% CI 1.56-3.84). In participants with normal glucose levels, PAI-1 (OR=2.06, 95% CI 1.10 - 3.86) exhibited an independent relationship with incident T2DM after the adjustments.Conclusions: Elevated levels of fibrinolytic variables precede the manifestation of T2DM after adjusting for metabolic and cardiovascular risk factors and can be detected several years before changes in glucose tolerance.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
- Diabetes mellitus type 2
- Tissue plasminogen activator
- Plasminogen activator inhibitor-1
- Von Willebrand factor
- Fibrinolysis
- Population study
- Vasterbotten Intervention Programme
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Norberg, MargaretaUmeå universitet,Epidemiologi och global hälsa(Swepub:umu)mano0062 (författare)
- Jansson, Jan-HåkanUmeå universitet,Medicin(Swepub:umu)jaja0006 (författare)
- Eliasson, MatsUmeå universitet,Medicin,Department of Medicine, Sunderby Hospital, Luleå, Sweden(Swepub:umu)mael0021 (författare)
- Eriksson, Jan WDepartment of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Gothenburg and AstraZeneca R&D, Mölndal, Sweden(Swepub:uu)janer909 (författare)
- Lindahl, BerntUmeå universitet,Yrkes- och miljömedicin(Swepub:umu)beli0020 (författare)
- Johansson, LarsUmeå universitet,Medicin(Swepub:umu)lasjon01 (författare)
- Umeå universitetMedicin (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Cardiovascular Diabetology: BioMed Central11, s. 152-1475-2840
Internetlänk
- https://doi.org/10.1186/1475-2840-11-152Fulltext
- https://umu.diva-portal.org/smash/get/diva2:609762/FULLTEXT02.pdffulltext:print
- https://cardiab.biomedcentral.com/track/pdf/10.1186/1475-2840-11-152
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-64956
- https://doi.org/10.1186/1475-2840-11-152
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-220695
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- Cardiovascular Diabetology (Sök värdpublikationen i LIBRIS)
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