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Evaluation of an at...
Evaluation of an attenuation correction method for PET/MR imaging of the head based on substitute CT images
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- Larsson, Anne (author)
- Umeå universitet,Radiofysik
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- Johansson, Adam (author)
- Umeå universitet,Radiofysik
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- Axelsson, Jan (author)
- Umeå universitet,Radiofysik
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- Nyholm, Tufve (author)
- Umeå universitet,Radiofysik
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- Asklund, Thomas (author)
- Umeå universitet,Radiofysik
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- Riklund, Katrine (author)
- Umeå universitet,Diagnostisk radiologi
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- Karlsson, Mikael (author)
- Umeå universitet,Radiofysik
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(creator_code:org_t)
- 2012-09-07
- 2013
- English.
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In: Magnetic Resonance Materials in Physics, Biology and Medicine. - : Springer Science and Business Media LLC. - 0968-5243 .- 1352-8661. ; 26:1, s. 127-136
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The aim of this study was to evaluate MR-based attenuation correction of PET emission data of the head, based on a previously described technique that calculates substitute CT (sCT) images from a set of MR images. Images from eight patients, examined with F-18-FLT PET/CT and MRI, were included. sCT images were calculated and co-registered to the corresponding CT images, and transferred to the PET/CT scanner for reconstruction. The new reconstructions were then compared with the originals. The effect of replacing bone with soft tissue in the sCT-images was also evaluated. The average relative difference between the sCT-corrected PET images and the CT-corrected PET images was 1.6 % for the head and 1.9 % for the brain. The average standard deviations of the relative differences within the head were relatively high, at 13.2 %, primarily because of large differences in the nasal septa region. For the brain, the average standard deviation was lower, 4.1 %. The global average difference in the head when replacing bone with soft tissue was 11 %. The method presented here has a high rate of accuracy, but high-precision quantitative imaging of the nasal septa region is not possible at the moment.
Keyword
- PET/MR
- Attenuation correction
- Substitute CT
- F-18-FLT
- UTE
Publication and Content Type
- ref (subject category)
- art (subject category)
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