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(WFRF:(van der Schouw Yvonne T.)) pers:(Sharp Stephen J.)
 

Search: (WFRF:(van der Schouw Yvonne T.)) pers:(Sharp Stephen J.) > (2012-2014) > Age at Menopause, R...

  • Brand, Judith S. (author)

Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-03-14
  • American Diabetes Association,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-68470
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-68470URI
  • https://doi.org/10.2337/dc12-1020DOI
  • https://lup.lub.lu.se/record/3765004URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE-Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk.RESEARCH DESIGN AND METHODS-Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied.RESULTS-Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04-1.69), 1.09 (0.90-1.31), 0.97 (0.86-1.10), and 0.85 (0.70-1.03) for women with menopause at ages <40, 40-44, 45-49, and >= 55 years, respectively, relative to those with menopause at age 50-54 years. The HR per SD younger age at menopause was 1.08 (1.02-1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [ 1.01-1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05).CONCLUSIONS-Early menopause is associated with a greater risk of type 2 diabetes. Diabetes Care 36:1012-1019, 2013

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • van der Schouw, Yvonne T. (author)
  • Onland-Moret, N. Charlotte (author)
  • Sharp, Stephen J. (author)
  • Ong, Ken K. (author)
  • Khaw, Kay-Tee (author)
  • Ardanaz, Eva (author)
  • Amiano, Pilar (author)
  • Boeing, Heiner (author)
  • Chirlaque, Maria-Dolores (author)
  • Clavel-Chapelon, Francoise (author)
  • Crowe, Francesca L. (author)
  • de Lauzon-Guillain, Blandine (author)
  • Duell, Eric J. (author)
  • Fagherazzi, Guy (author)
  • Franks, Paul W.Lund University,Lunds universitet,Umeå universitet,Medicin,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)med-plf (author)
  • Grioni, Sara (author)
  • Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr (author)
  • Kaaks, Rudolf (author)
  • Key, Timothy J. (author)
  • Nilsson, PeterLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (author)
  • Overvad, Kim (author)
  • Palli, Domenico (author)
  • Panico, Salvatore (author)
  • Quiros, J. Ramon (author)
  • Rolandsson, OlovUmeå universitet,Allmänmedicin(Swepub:umu)olro0005 (author)
  • Sacerdote, Carlotta (author)
  • Sanchez, Maria-Jose (author)
  • Slimani, Nadia (author)
  • Teucher, Birgit (author)
  • Tjonneland, Anne (author)
  • Tumino, Rosario (author)
  • van der A, Daphne L. (author)
  • Feskens, Edith J. M. (author)
  • Langenberg, Claudia (author)
  • Forouhi, Nita G. (author)
  • Riboli, Elio (author)
  • Wareham, Nicholas J. (author)
  • Umeå universitetMedicin (creator_code:org_t)

Related titles

  • In:Diabetes Care: American Diabetes Association36:4, s. 1012-10190149-59921935-5548

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