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  • Michels, Judith (author)

Cisplatin Resistance Associated with PARP Hyperactivation

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • Philadelphia :American Association for Cancer Research,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-70139
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-70139URI
  • https://doi.org/10.1158/0008-5472.CAN-12-3000DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Non-small cell lung carcinoma patients are frequently treated with cisplatin (CDDP), most often yielding temporary clinical responses. Here, we show that PARP1 is highly expressed and constitutively hyperactivated in a majority of human CDDP-resistant cancer cells of distinct histologic origin. Cells manifesting elevated intracellular levels of poly(ADP-ribosyl)ated proteins (PAR(high)) responded to pharmacologic PARP inhibitors as well as to PARP1-targeting siRNAs by initiating a DNA damage response that translated into cell death following the activation of the intrinsic pathway of apoptosis. Moreover, PARP1-overexpressing tumor cells and xenografts displayed elevated levels of PAR, which predicted the response to PARP inhibitors in vitro and in vivo more accurately than PARP1 expression itself. Thus, a majority of CDDP-resistant cancer cells appear to develop a dependency to PARP1, becoming susceptible to PARP inhibitor-induced apoptosis. Cancer Res; 73(7); 2271-80.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Vitale, Ilio (author)
  • Galluzzi, Lorenzo (author)
  • Adam, Julien (author)
  • Olaussen, Ken Andre (author)
  • Kepp, Oliver (author)
  • Senovilla, Laura (author)
  • Talhaoui, Ibtissam (author)
  • Guegan, Justine (author)
  • Enot, David Pierre (author)
  • Talbot, Monique (author)
  • Robin, Angelique (author)
  • Girard, Philippe (author)
  • Orear, Cedric (author)
  • Lissa, Delphine (author)
  • Sukkurwala, Abdul Qader (author)
  • Garcia, Pauline (author)
  • Behnam Motlagh, ParvizUmeå universitet,Klinisk kemi(Swepub:umu)pabe0001 (author)
  • Kohno, Kimitoshi (author)
  • Wu, Gen Sheng (author)
  • Brenner, Catherine (author)
  • Dessen, Philippe (author)
  • Saparbaev, Murat (author)
  • Soria, Jean-Charles (author)
  • Castedo, Maria (author)
  • Kroemer, Guido (author)
  • Umeå universitetKlinisk kemi (creator_code:org_t)

Related titles

  • In:Cancer ResearchPhiladelphia : American Association for Cancer Research73:7, s. 2271-22800008-54721538-7445

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