Search: onr:"swepub:oai:DiVA.org:umu-70152" >
Neurogenin 3(+) cel...
-
Van de Casteele, M.
(author)
Neurogenin 3(+) cells contribute to beta-cell neogenesis and proliferation in injured adult mouse pancreas
- Article/chapterEnglish2013
Publisher, publication year, extent ...
-
2013-03-07
-
London :Nature Publishing Group,2013
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:umu-70152
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-70152URI
-
https://doi.org/10.1038/cddis.2013.52DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3)(+) progenitor cells that can differentiate to beta cells ex vivo. Here we evaluate the role of Ngn3(+) cells in beta cell expansion in situ. PDL not only induced doubling of the beta cell volume but also increased the total number of islets. beta cells proliferated without extended delay (the so-called 'refractory' period), their proliferation potential was highest in small islets, and 86% of the beta cell expansion was attributable to proliferation of pre-existing beta cells. At sufficiently high Ngn3 expression level, upto 14% of all beta cells and 40% of small islet beta cells derived from non-beta cells. Moreover, beta cell proliferation was blunted by a selective ablation of Ngn3(+) cells but not by conditional knockout of Ngn3 in pre-existing beta cells supporting a key role for Ngn3(+) insulin(-) cells in beta cell proliferation and expansion. We conclude that Ngn3(+) cell-dependent proliferation of pre-existing and newly-formed beta cells as well as reprogramming of non-beta cells contribute to in vivo beta cell expansion in the injured pancreas of adult mice.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Leuckx, G.
(author)
-
Baeyens, L.
(author)
-
Cai, Y.
(author)
-
Yuchi, Y.
(author)
-
Coppens, V.
(author)
-
De Groef, S.
(author)
-
Eriksson, MariaUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)maer0057
(author)
-
Svensson, ChristofferUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)chsv0004
(author)
-
Ahlgren, UlfUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)ulah0001
(author)
-
Ahnfelt-Ronne, J.
(author)
-
Madsen, O. D.
(author)
-
Waisman, A.
(author)
-
Dor, Y.
(author)
-
Jensen, J. N.
(author)
-
Heimberg, H.
(author)
-
Umeå universitetUmeå centrum för molekylär medicin (UCMM)
(creator_code:org_t)
Related titles
-
In:Cell Death and DiseaseLondon : Nature Publishing Group4, s. e523-2041-4889
Internet link
Find in a library
To the university's database
- By the author/editor
-
Van de Casteele, ...
-
Leuckx, G.
-
Baeyens, L.
-
Cai, Y.
-
Yuchi, Y.
-
Coppens, V.
-
show more...
-
De Groef, S.
-
Eriksson, Maria
-
Svensson, Christ ...
-
Ahlgren, Ulf
-
Ahnfelt-Ronne, J ...
-
Madsen, O. D.
-
Waisman, A.
-
Dor, Y.
-
Jensen, J. N.
-
Heimberg, H.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
Cell Death and D ...
- By the university
-
Umeå University