Pre- and postsynaptic dopamine SPECT in idiopathic parkinsonian diseases: a follow-up study

Pre- and postsynaptic dopamine SPECT in idiopathic parkinsonian diseases : a follow-up study

Originally published in thesis in manuscript form
We prospectively evaluated the diagnostic contribution of 123I-FP-Cit (DAT) and 123I-IBZM (IBZM) SPECT in 29 patients with Parkinson’s disease (PD) (74.4 ± 4.2 years) and 28 patients with atypical parkinsonian diseases (APD) (74.3 ± 9.2 years). Twelve had multiple system atrophy (MSA) and 16 progressive supranuclear palsy (PSP). Sixteen age-matched healthy controls (HC) were included. DAT and IBZM SPECTs were made at baseline and after 1 year in all PD patients and in 20 (DAT) and 18 (IBZM) of the APD patients, and after 3 years in 22 (DAT) and 17 (IBZM) of the PD patients and in 10 (DAT) and 10 (IBZM) of the APD patients. The relative DAT uptake decrease was faster in PD and PSP than in HC and MSA. In PSP the DAT uptake was lower than in MSA after 1 year but not after 3 years. Baseline IBZM uptake was not significantly different between patients and HC or between PD and APD. One year after initiated dopaminergic treatment the mean IBZM uptake in the MSA patients remained high compared to PSP and after 3 years compared to PD, PSP, and HC.Thus, the pattern of uptake of these ligands over time may be of value in discriminating between these diagnoses.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
Parkinson’s disease
Multiple System Atrophy
Progressive Supranuclear Palsy
SPECT
123I-FP-Cit
123I-IBZM
prospective study
Radiology
radiologi

Linder, JanUmeå universitet,Klinisk neurovetenskap(Swepub:umu)jali0020 (författare)
Forsgren, LarsUmeå universitet,Klinisk neurovetenskap(Swepub:umu)lafo0001 (författare)
Holmberg, HenrikUmeå universitet,Statistik (författare)
Larsson, AnneUmeå universitet,Radiofysik(Swepub:umu)anelan97 (författare)
Riklund, KatrineUmeå universitet,Diagnostisk radiologi(Swepub:umu)kaah0001 (författare)
Umeå universitetDiagnostisk radiologi (creator_code:org_t)

Ingår i:BioMed Research International: Hindawi Limited2013, s. 143532-2314-61412314-6133

Av författaren/redakt...: Jakobson Mo, Sus ...; Linder, Jan; Forsgren, Lars; Holmberg, Henrik; Larsson, Anne; Riklund, Katrine

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Radiologi och bi ...

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