Sökning: WFRF:(Johansson Pernilla)
> (2005-2009) >
Evaluation of intes...
Evaluation of intestinal preconditioning in a porcine model using classic ischemic preconditioning or lung recruitment maneuvers.
-
- Claesson, Jonas (författare)
- Umeå universitet,Anestesiologi och intensivvård
-
- Lehtipalo, Stefan (författare)
- Umeå universitet,Anestesiologi och intensivvård
-
- Johansson, Göran (författare)
- Umeå universitet,Anestesiologi och intensivvård
-
visa fler...
-
- Abrahamsson, Pernilla (författare)
- Umeå universitet,Anestesiologi och intensivvård
-
- Palmqvist, Richard (författare)
- Umeå universitet,Patologi
-
- Biber, Björn, 1944 (författare)
- Gothenburg University,Göteborgs universitet,Umeå universitet,Anestesiologi och intensivvård,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
-
- Winsö, Ola (författare)
- Umeå universitet,Anestesiologi och intensivvård
-
visa färre...
-
(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2008
- 2008
- Engelska.
-
Ingår i: Shock. - : Ovid Technologies (Wolters Kluwer Health). - 1073-2322 .- 1540-0514. ; 21:1, s. 98-103
- Relaterad länk:
-
http://www.ncbi.nlm....
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
http://umu.diva-port...
-
https://urn.kb.se/re...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- To test the hypotheses that repeated brief intestinal ischemic insults would elicit an intestinal preconditioning response to a subsequent intestinal I/R injury and that a similar response would be elicited by repeated lung recruitment maneuvers (RMs). Randomized experimental controlled animal study. University hospital animal laboratory. Eighteen anesthetized pigs. Animals were randomized to one of three groups, with six animals in each group. Control group 75-min superior mesenteric artery (SMA) occlusion followed by 60-min reperfusion. Ischemic preconditioning group, three 5-min-long SMA occlusions preceding 75-min SMA occlusion and 60-min reperfusion. Recruitment maneuver (RM) group, three 2-min-long RMs preceding 75-min SMA occlusion and 60-min reperfusion. We measured systemic and mesenteric hemodynamic parameters, jejunal mucosal perfusion, net mesenteric lactate flux, jejunal tissue oxygen tension, and mesenteric oxygenation. Every 15 min, jejunal microdialysate samples were collected and analyzed for glucose, lactate, and glycerol. Jejunal tissue samples were collected postmortem. After occlusion of SMA, regional parameters in all groups indicated abolished perfusion and gradually increasing intraluminal microdialysate lactate and glycerol levels. At reperfusion, regional parameters indicated mesenteric hyperperfusion, whereas microdialysis markers of mucosal anaerobic metabolism and cell injury decreased, although not reaching baseline. Histological examination revealed severe mucosal injury in all groups. There were no significant differences between groups in the observed parameters. No protective preconditioning response could be observed when performing repeated brief intestinal ischemic insults or repeated lung RMs before an intestinal I/R injury.
Nyckelord
- Animals
- Blood Pressure/physiology
- Epinephrine/pharmacology
- Isoflurane/pharmacology
- Myocardial Contraction/*drug effects/physiology
- Myocardial Revascularization/methods
- Stroke Volume
- Swine
- Vasoconstrictor Agents/pharmacology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Shock
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas