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Genome-wide meta-an...
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Berndt, Sonja I.
(author)
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013-04-07
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Springer Science and Business Media LLC,2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-71608
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-71608URI
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https://doi.org/10.1038/ng.2606DOI
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https://lup.lub.lu.se/record/3843496URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-200675URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:126660018URI
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https://gup.ub.gu.se/publication/181095URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Gustafsson, StefanUppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden(Swepub:uu)stegu732
(author)
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Maegi, Reedik
(author)
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Ganna, AndreaKarolinska Institutet
(author)
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Wheeler, Eleanor
(author)
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Feitosa, Mary F.
(author)
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Justice, Anne E.
(author)
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Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind
(author)
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Croteau-Chonka, Damien C.
(author)
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Day, Felix R.
(author)
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Esko, Tonu
(author)
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Fall, Tove,1979-Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden(Swepub:uu)tovfa878
(author)
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Ferreira, Teresa
(author)
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Gentilini, Davide
(author)
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Jackson, Anne U.
(author)
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Luan, Jian'an
(author)
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Randall, Joshua C.
(author)
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Vedantam, Sailaja
(author)
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Willer, Cristen J.
(author)
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Winkler, Thomas W.
(author)
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Wood, Andrew R.
(author)
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Workalemahu, Tsegaselassie
(author)
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Hu, Yi-Juan
(author)
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Lee, Sang Hong
(author)
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Liang, Liming
(author)
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Lin, Dan-Yu
(author)
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Min, Josine L.
(author)
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Neale, Benjamin M.
(author)
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Thorleifsson, Gudmar
(author)
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Yang, Jian
(author)
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Albrecht, Eva
(author)
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Amin, Najaf
(author)
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Bragg-Gresham, Jennifer L.
(author)
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Cadby, Gemma
(author)
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den Heijer, Martin
(author)
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Eklund, Niina
(author)
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Fischer, Krista
(author)
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Goel, Anuj
(author)
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Hottenga, Jouke-Jan
(author)
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Huffman, Jennifer E.
(author)
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Jarick, Ivonne
(author)
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Johansson, ÅsaUppsala universitet,Genomik,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)asjoh108
(author)
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Johnson, Toby
(author)
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Kanoni, Stavroula
(author)
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Kleber, Marcus E.
(author)
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Koenig, Inke R.
(author)
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Kristiansson, KatiKarolinska Institutet
(author)
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Kutalik, Zoltn
(author)
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Lamina, Claudia
(author)
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Lecoeur, Cecile
(author)
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Li, Guo
(author)
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Mangino, Massimo
(author)
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McArdle, Wendy L.
(author)
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Medina-Gomez, Carolina
(author)
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Mueller-Nurasyid, Martina
(author)
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Ngwa, Julius S.
(author)
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Nolte, Ilja M.
(author)
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Paternoster, Lavinia
(author)
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Pechlivanis, Sonali
(author)
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Perola, Markus
(author)
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Peters, Marjolein J.
(author)
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Preuss, Michael
(author)
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Rose, Lynda M.
(author)
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Shi, Jianxin
(author)
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Shungin, DmitryLund University,Lunds universitet,Umeå universitet,Medicin,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology(Swepub:lu)med-dsn
(author)
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Smith, Albert Vernon
(author)
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Strawbridge, Rona J.Karolinska Institutet
(author)
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Surakka, Ida
(author)
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Teumer, Alexander
(author)
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Trip, Mieke D.
(author)
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Tyrer, Jonathan
(author)
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Van Vliet-Ostaptchouk, Jana V.
(author)
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Vandenput, Liesbeth,1974Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xvanli
(author)
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Waite, Lindsay L.
(author)
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Zhao, Jing Hua
(author)
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Absher, Devin
(author)
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Asselbergs, Folkert W.
(author)
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Atalay, Mustafa
(author)
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Attwood, Antony P.
(author)
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Balmforth, Anthony J.
(author)
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Basart, Hanneke
(author)
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Beilby, John
(author)
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Bonnycastle, Lori L.
(author)
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Brambilla, Paolo
(author)
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Bruinenberg, Marcel
(author)
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Campbell, Harry
(author)
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Chasman, Daniel I.
(author)
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Chines, Peter S.
(author)
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Collins, Francis S.
(author)
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Connell, John M.
(author)
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Cookson, William O.
(author)
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de Faire, UlfKarolinska Institutet
(author)
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de Vegt, Femmie
(author)
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Dei, Mariano
(author)
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Dimitriou, Maria
(author)
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Edkins, Sarah
(author)
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Estrada, Karol
(author)
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Evans, David M.
(author)
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Farrall, Martin
(author)
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Ferrario, Marco M.
(author)
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Ferrieres, Jean
(author)
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Franke, Lude
(author)
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Frau, Francesca
(author)
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Gejman, Pablo V.
(author)
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Grallert, Harald
(author)
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Groenberg, HenrikKarolinska Institutet
(author)
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Gudnason, Vilmundur
(author)
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Hall, Alistair S.
(author)
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Hall, PerKarolinska Institutet
(author)
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Hartikainen, Anna-Liisa
(author)
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Hayward, Caroline
(author)
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Heard-Costa, Nancy L.
(author)
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Heath, Andrew C.
(author)
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Hebebrand, Johannes
(author)
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Homuth, Georg
(author)
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Hu, Frank B.
(author)
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Hunt, Sarah E.
(author)
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Hyppoenen, Elina
(author)
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Iribarren, Carlos
(author)
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Jacobs, Kevin B.
(author)
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Jansson, John-Olov,1954Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xjanjo
(author)
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Jula, Antti
(author)
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Kahonen, Mika
(author)
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Kathiresan, Sekar
(author)
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Kee, Frank
(author)
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Khaw, Kay-Tee
(author)
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Kivimaki, Mika
(author)
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Koenig, Wolfgang
(author)
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Kraja, Aldi T.
(author)
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Kumari, Meena
(author)
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Kuulasmaa, Kari
(author)
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Kuusisto, Johanna
(author)
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Laitinen, Jaana H.
(author)
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Lakka, Timo A.
(author)
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Langenberg, Claudia
(author)
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Launer, Lenore J.
(author)
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Lind, Lars
(author)
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Lindstrom, Jaana
(author)
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Liu, Jianjun
(author)
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Liuzzi, Antonio
(author)
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Lokki, Marja-Liisa
(author)
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Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research(Swepub:gu)xlomat
(author)
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Madden, Pamela A.
(author)
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Magnusson, Patrik K.
(author)
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Manunta, Paolo
(author)
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Marek, Diana
(author)
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Maerz, Winfried
(author)
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Leach, Irene Mateo
(author)
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McKnight, Barbara
(author)
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Medland, Sarah E.
(author)
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Mihailov, Evelin
(author)
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Milani, Lili
(author)
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Montgomery, Grant W.
(author)
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Mooser, Vincent
(author)
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Muehleisen, Thomas W.
(author)
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Munroe, Patricia B.
(author)
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Musk, Arthur W.
(author)
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Narisu, NarisuKarolinska Institutet
(author)
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Navis, Gerjan
(author)
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Nicholson, George
(author)
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Nohr, Ellen A.
(author)
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Ong, Ken K.
(author)
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Oostra, Ben A.
(author)
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Palmer, Colin N. A.
(author)
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Palotie, Aarno
(author)
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Peden, John F.
(author)
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Pedersen, Nancy
(author)
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Peters, Annette
(author)
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Polasek, Ozren
(author)
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Pouta, Anneli
(author)
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Pramstaller, Peter P.
(author)
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Prokopenko, Inga
(author)
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Puetter, Carolin
(author)
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Radhakrishnan, Aparna
(author)
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Raitakari, Olli
(author)
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Rendon, Augusto
(author)
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Rivadeneira, Fernando
(author)
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Rudan, Igor
(author)
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Saaristo, Timo E.
(author)
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Sambrook, Jennifer G.
(author)
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Sanders, Alan R.
(author)
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Sanna, Serena
(author)
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Saramies, Jouko
(author)
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Schipf, Sabine
(author)
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Schreiber, Stefan
(author)
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Schunkert, Heribert
(author)
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Shin, So-Youn
(author)
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Signorini, Stefano
(author)
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Sinisalo, Juha
(author)
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Skrobek, Boris
(author)
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Soranzo, Nicole
(author)
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Stancakova, Alena
(author)
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Stark, Klaus
(author)
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Stephens, Jonathan C.
(author)
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Stirrups, Kathleen
(author)
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Stolk, Ronald P.
(author)
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Stumvoll, Michael
(author)
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Swift, Amy J.
(author)
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Theodoraki, Eirini V.
(author)
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Thorand, Barbara
(author)
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Tregouet, David-Alexandre
(author)
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Tremoli, Elena
(author)
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Van der Klauw, Melanie M.
(author)
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van Meurs, Joyce B. J.
(author)
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Vermeulen, Sita H.
(author)
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Viikari, Jorma
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Virtamo, Jarmo
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Vitart, Veronique
(author)
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Waeber, Gerard
(author)
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Wang, Zhaoming
(author)
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Widen, Elisabeth
(author)
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Wild, Sarah H.
(author)
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Willemsen, Gonneke
(author)
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Winkelmann, Bernhard R.
(author)
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Witteman, Jacqueline C. M.
(author)
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Wolffenbuttel, Bruce H. R.
(author)
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Wong, Andrew
(author)
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Wright, Alan F.
(author)
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Zillikens, M. Carola
(author)
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Amouyel, Philippe
(author)
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Boehm, Bernhard O.
(author)
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Boerwinkle, Eric
(author)
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Boomsma, Dorret I.
(author)
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Caulfield, Mark J.
(author)
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Chanock, Stephen J.
(author)
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Cupples, L. Adrienne
(author)
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Cusi, Daniele
(author)
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Dedoussis, George V.
(author)
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Erdmann, Jeanette
(author)
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Eriksson, Johan G.
(author)
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Franks, Paul W.Lund University,Lunds universitet,Umeå universitet,Medicin,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology(Swepub:lu)med-plf
(author)
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Froguel, Philippe
(author)
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Gieger, Christian
(author)
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Gyllensten, UlfUppsala universitet,Genomik(Swepub:uu)ulfgyll
(author)
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Hamsten, AndersKarolinska Institutet
(author)
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Harris, Tamara B.
(author)
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Hengstenberg, Christian
(author)
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Hicks, Andrew A.
(author)
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Hingorani, Aroon
(author)
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Hinney, Anke
(author)
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Hofman, Albert
(author)
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Hovingh, Kees G.
(author)
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Hveem, Kristian
(author)
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Illig, Thomas
(author)
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Jarvelin, Marjo-Riitta
(author)
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Joeckel, Karl-Heinz
(author)
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Keinanen-Kiukaanniemi, Sirkka M.
(author)
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Kiemeney, Lambertus A.
(author)
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Kuh, Diana
(author)
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Laakso, Markku
(author)
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Lehtimaki, Terho
(author)
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Levinson, Douglas F.
(author)
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Martin, Nicholas G.
(author)
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Metspalu, Andres
(author)
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Morris, Andrew D.
(author)
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Nieminen, Markku S.
(author)
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Njolstad, Inger
(author)
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xohlcl
(author)
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Oldehinkel, Albertine J.
(author)
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Ouwehand, Willem H.
(author)
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Palmer, Lyle J.
(author)
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Penninx, Brenda
(author)
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Power, Chris
(author)
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Province, Michael A.
(author)
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Psaty, Bruce M.
(author)
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Qi, Lu
(author)
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Rauramaa, Rainer
(author)
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Ridker, Paul M.
(author)
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Ripatti, Samuli
(author)
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Salomaa, Veikko
(author)
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Samani, Nilesh J.
(author)
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Snieder, Harold
(author)
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Sorensen, Thorkild I. A.
(author)
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Spector, Timothy D.
(author)
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Stefansson, Kari
(author)
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Tonjes, Anke
(author)
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Tuomilehto, Jaakko
(author)
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Uitterlinden, Andre G.
(author)
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Uusitupa, Matti
(author)
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van der Harst, Pim
(author)
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Vollenweider, Peter
(author)
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Wallaschofski, Henri
(author)
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Wareham, Nicholas J.
(author)
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Watkins, Hugh
(author)
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Wichmann, H-Erich
(author)
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Wilson, James F.
(author)
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Abecasis, Goncalo R.
(author)
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Assimes, Themistocles L.
(author)
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Barroso, Ines
(author)
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Boehnke, Michael
(author)
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Borecki, Ingrid B.
(author)
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Deloukas, Panos
(author)
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Fox, Caroline S.
(author)
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Frayling, Timothy
(author)
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
(author)
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Haritunian, Talin
(author)
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Heid, Iris M.
(author)
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Hunter, David
(author)
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Kaplan, Robert C.
(author)
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Karpe, Fredrik
(author)
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Moffatt, Miriam F.
(author)
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Mohlke, Karen L.
(author)
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O'Connell, Jeffrey R.
(author)
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Pawitan, YudiKarolinska Institutet
(author)
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Schadt, Eric E.
(author)
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Schlessinger, David
(author)
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Steinthorsdottir, Valgerdur
(author)
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Strachan, David P.
(author)
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Thorsteinsdottir, Unnur
(author)
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van Duijn, Cornelia M.
(author)
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Visscher, Peter M.
(author)
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Di Blasio, Anna Maria
(author)
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Hirschhorn, Joel N.
(author)
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Lindgren, Cecilia M.
(author)
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Morris, Andrew P.
(author)
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Meyre, David
(author)
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Scherag, Andr
(author)
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McCarthy, Mark I.
(author)
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Speliotes, Elizabeth K.
(author)
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North, Kari E.
(author)
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Loos, Ruth J. F.
(author)
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Ingelsson, Erik,1975-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK;Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK(Swepub:uu)ering425
(author)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC45:5, s. 501-U691061-40361546-1718
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Berndt, Sonja I.
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Ganna, Andrea
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Wheeler, Eleanor
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Feitosa, Mary F.
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Lind, Lars
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Jula, Antti
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Kahonen, Mika
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Kathiresan, Seka ...
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Kee, Frank
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Khaw, Kay-Tee
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Kivimaki, Mika
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Koenig, Wolfgang
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Kraja, Aldi T.
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Kumari, Meena
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Kuulasmaa, Kari
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Kuusisto, Johann ...
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Lakka, Timo A.
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Langenberg, Clau ...
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Magnusson, Patri ...
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Palotie, Aarno
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Umeå University
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Lund University
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Uppsala University
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Karolinska Institutet
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University of Gothenburg