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Viral load and humo...
Viral load and humoral immune response in association with disease severity in Puumala hantavirus-infected patients-implications for treatment
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- Pettersson, Lisa (författare)
- Umeå universitet,Virologi
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- Thunberg, Therese, 1977- (författare)
- Umeå universitet,Infektionssjukdomar
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- Rocklöv, Joacim (författare)
- Umeå universitet,Epidemiologi och global hälsa,Arcum
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- Klingström, Jonas (författare)
- Karolinska Institutet
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- Evander, Magnus (författare)
- Umeå universitet,Virologi,Arcum
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- Ahlm, Clas (författare)
- Umeå universitet,Infektionssjukdomar,Arcum
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(creator_code:org_t)
- Wiley-Blackwell, 2014
- 2014
- Engelska.
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Ingår i: Clinical Microbiology and Infection. - : Wiley-Blackwell. - 1198-743X .- 1469-0691. ; 20:3, s. 235-241
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://www.clinicalm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Hantaviruses are the causative agents of haemorrhagic fever with renal syndrome (HFRS) in Eurasia and of hantavirus cardiopulmonary syndrome (HCPS) in the Americas. The case fatality rate varies between different hantaviruses and can be up to 40%. At present, there is no specific treatment available. The hantavirus pathogenesis is not well understood, but most likely, both virus-mediated and host-mediated mechanisms are involved. The aim of the present study was to investigate the association among Puumala hantavirus (PUUV) viral RNA load, humoral immune response and disease severity in patients with HFRS. We performed a study of 105 PUUV-infected patients that were followed during the acute phase of disease and for up to 1-3 months later. Fifteen of the 105 patients (14%) were classified as having moderate/severe disease. A low PUUV-specific IgG response (p <0.05) and also a higher white blood cell count (p <0.001) were significantly associated with more severe disease. The PUUV RNA was detected in a majority of patient plasma samples up to 9 days after disease onset; however, PUUV RNA load or longevity of viraemia were not significantly associated with disease severity. We conclude that a low specific IgG response was associated with disease severity in patients with HFRS, whereas PUUV RNA load did not seem to affect the severity of HFRS. Our results raise the possibility of passive immunotherapy as a useful treatment for hantavirus-infected patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- age
- disease severity
- hantavirus
- haemorrhagic fever with renal syndrome
- humoral immune response
- immunoglobulins
- neutrophil
- Puumala virus
- viral load
- white blood cell count
- mikrobiologi
- Microbiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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