WFRF:(Yu Cheuk Man)
Sökning: WFRF:(Yu Cheuk Man) > Right ventricular l...
- Fang, Fang (författare)
Right ventricular long-axis response to different chronic loading conditions : Its relevance to clinical symptoms
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
- Elsevier BV,2013
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:umu-79039
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79039URI
- https://doi.org/10.1016/j.ijcard.2011.12.086DOI
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- Språk:engelska
- Sammanfattning på:engelska
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Anmärkningar
- Background: The intervention timing in atrial septal defect (ASD) or pulmonary valvular stenosis (PVS) is more dependent on symptoms than right ventricular (RV) damage in clinical practice. RV long-axis function is sensitive in revealing RV myocardial dysfunction. We evaluate the impact of different chronic loading conditions on RV long-axis function and its relationship to patients' symptoms in ASD or PVS. Methods: Transthoracic echocardiography was performed in normals (n=39) and patients with isolated secundum ASD (n=45) or PVS (n=38). RV volume- and pressure-overloading were defined as the ratio of RV/left ventricular end-diastolic dimension >= 0.5 and RV systolic pressure >= 40 mm Hg, respectively. RV long-axis dysfunction was defined as M-mode tricuspid annular plane systolic excursion (TAPSE) <1.6 cm. New York Heart Association (NYHA) functional class and other symptoms (decreased exercise tolerance, palpitation and chest pain) were recorded. Results: Thirty-nine (32.0%) had normal loading (Group 1; 39 normals); 24 (19.6%) had isolated volume-overloading (Group 2; all ASDs); 21 (17.2%) had isolated pressure-overloading (Group 3; 21 PVSs) and 38 (31.1%) had both overloading conditions (Group 4; 21 ASDs and 17 PVSs). RV long-axis dysfunction in abnormal loading groups were zero (0%, Group 2), 21 (100%, Group 3) and 22 (57.8%, Group 4) (chi(2)=45.9, p<0.001). Group 3 were more symptomatic (NYHA functional class 2.5 +/- 0.6 versus 1.6 +/- 0.5, p<0.05) and had lower TAPSE (1.6 +/- 0.4 versus 3.0 +/- 0.7 cm, p<0.05) than Group 2. RV long-axis dysfunction was the strongest predictor of the presence of symptoms (odds ratio=9.298, p<0.001). Conclusion: Chronic volume-overloading accentuates while pressure-overloading attenuates RV long-axis excursion and its impairment was associated with the presence of symptoms.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- Right ventricular function
- Volume overloading
- Pressure overloading
- Tricuspid annular plane systolic excursion
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Henein, Micheal Y.Umeå universitet,Kardiologi,Umeå Heart Centre(Swepub:umu)mihe0015 (författare)
- Yu, Cheuk-Man (författare)
- Li, Wei (författare)
- Kaya, Mehmet G. (författare)
- Coats, Andrew J. (författare)
- Lam, Yat-Yin (författare)
- Umeå universitetKardiologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:International Journal of Cardiology: Elsevier BV167:2, s. 378-3820167-52731874-1754
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- International Journal of Cardiology (Sök värdpublikationen i LIBRIS)
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