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- Holmberg, EllinorUmeå universitet,Obstetrik och gynekologi,UNC (author)
Allopregnanolone induces a diurnally dependent hyperphagic effect and alters feeding latency and duration in male Wistar rats
- Article/chapterEnglish2013
Publisher, publication year, extent ...
- 2013-04-17
- John Wiley & Sons,2013
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-79224
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79224URI
- https://doi.org/10.1111/apha.12100DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Aim: Gamma-aminobutyric acid (GABA)-ergic transmission from the hypothalamus is essential for normal feeding regulation, and hyperphagia can be induced by local application of GABA(A)-receptor agonists to different feeding-associated brain areas. The food intake in rats varies diurnally and that may influence the effect of GABA(A)-receptor active compounds. The progesterone metabolite allopregnanolone is a highly potent endogenous positive modulator of the GABA(A) receptor. Therefore, it is easy to envisage that allopregnanolone would have a hyperphagic effect, but earlier reports in rat have given ambiguous results. However, a contributing factor for the discrepancy may be the time point of the diurnal cycle in which the experiments were performed. The aim of this study was to investigate the effect of allopregnanolone on intake of standard chow in male Wistar rats at different time points of the day.Methods: Chow intake was measured after acute administration of allopregnanolone, and feeding behaviour was analysed to detect meal patterns.Results: We found that allopregnanolone increased chow intake by up to four times in the dark part of the 24-h cycle. The rats ate significantly more, and the effect of allopregnanolone was more prominent in the active (dark) compared with the inactive (light) period. Allopregnanolone also reduced feeding latency and prolonged the meal duration compared with vehicle.Conclusion: Allopregnanolone seems to act at several levels of feeding regulation, that is, to initiate feeding and to prolong the duration of a meal, thereby increasing the meal size, especially in the dark period of the 24-h cycle.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
- allopregnanolone
- diurnal rhythm
- food intake
- Gamma-aminobutyric acid
- hyperphagia
- neurosteroids
Added entries (persons, corporate bodies, meetings, titles ...)
- Bäckström, Torbjörn,1948-Umeå universitet,Obstetrik och gynekologi,UNC(Swepub:umu)toba0001 (author)
- Johansson, MajaUmeå universitet,Obstetrik och gynekologi,UNC(Swepub:umu)injo0002 (author)
- Löfgren, MagnusUmeå universitet,Obstetrik och gynekologi,UNC(Swepub:umu)malo0017 (author)
- Haage, DavidUmeå universitet,Obstetrik och gynekologi,UNC(Swepub:umu)daha0002 (author)
- Umeå universitetObstetrik och gynekologi (creator_code:org_t)
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- In:Acta Physiologica: John Wiley & Sons208:4, s. 400-4091748-17081748-1716
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