SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Ortega Francisco B.)
 

Search: WFRF:(Ortega Francisco B.) > (2010-2014) > Cardiorespiratory f...

  • Labayen, Idoia (author)

Cardiorespiratory fitness modifies the association between the UCP3-55C>T (rs1800849) polymorphism and plasma homocysteine in Swedish youth

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • Elsevier BV,2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-79789
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79789URI
  • https://doi.org/10.1016/j.atherosclerosis.2009.11.030DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:120358385URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE: Whether the polymorphisms in the UCP3 gene have an influence on plasma homocysteine levels during youth is not known, and to elucidate the putative modifying role of fitness is also of clinical interest. We analysed the association between polymorphisms in the UCP3 gene and plasma homocysteine in youth and to examine whether fitness modifies this association.METHODS: The study population comprised 267 Swedish children (8-10 years) and 305 adolescents (14-16 years). Fasting total plasma homocysteine was the outcome variable. We genotyped five UCP3 polymorphisms (rs1800849, rs1800006, rs2075577, rs647126, and rs591758) and one MTHFR 677C>T (rs1801133) polymorphism. Cardiorespiratory fitness was measured with a maximal ergometer bike test.RESULTS: Youth homozygous or heterozygous for the T allele of the rs1800849 polymorphism had significantly higher levels of homocysteine than those carrying the CC genotype (8.56+/-4.72 micromol/L vs. 7.72+/-2.73 micromol/L, respectively, P=0.011) after adjusting for gender, age, pubertal status, folate and vitamin B(12) intake and MTHFR 677C>T polymorphism, whereas no association was observed for the other analysed polymorphisms. There was a significant interaction effect of fitnessxrs1800849 polymorphism (P=0.042). The effect of the rs1800849 polymorphism on homocysteine levels persisted in youth with low fitness, whereas it was abolished in those with moderate or high cardiorespiratory fitness (P>0.1).CONCLUSIONS: Cardiorespiratory fitness modifies the association between the rs1800849 polymorphism and homocysteine so that the negative effect of the T allele does not persist in youth with moderate to high levels of fitness.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Olsson, Lovisa A (author)
  • Ortega, Francisco BKarolinska Institutet (author)
  • Nilsson, Torbjörn KDepartment of Clinical Chemistry, Örebro University Hospital(Swepub:umu)toni0049 (author)
  • Sjöström, MichaelKarolinska Institutet (author)
  • Lucia, Alejandro (author)
  • Ruiz, Jonatan RKarolinska Institutet (author)
  • Karolinska InstitutetDepartment of Clinical Chemistry, Örebro University Hospital (creator_code:org_t)

Related titles

  • In:Atherosclerosis: Elsevier BV210:1, s. 183-1870021-91501879-1484

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view