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Indentation loading...
Indentation loading response of a resonance sensor : discriminating prostate cancer and normal tissue
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- Jalkanen, Ville (author)
- Umeå universitet,Institutionen för tillämpad fysik och elektronik,Centrum för medicinsk teknik och fysik (CMTF)
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- Andersson, Britt (author)
- Umeå universitet,Institutionen för tillämpad fysik och elektronik,Centrum för medicinsk teknik och fysik (CMTF)
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- Bergh, Anders (author)
- Umeå universitet,Patologi
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- Ljungberg, Börje (author)
- Umeå universitet,Urologi och andrologi,Njurcancer
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- Lindahl, Olof (author)
- Umeå universitet,Radiofysik,Centrum för medicinsk teknik och fysik (CMTF)
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(creator_code:org_t)
- 2013-08-27
- 2013
- English.
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In: Journal of Medical Engineering & Technology. - : Taylor & Francis. - 0309-1902 .- 1464-522X. ; 37:7, s. 416-423
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Prostate cancer is the most common type of cancer among men worldwide. Mechanical properties of prostate tissue are promising for distinguishing prostate cancer from healthy prostate tissue. The aim was to investigate the indentation loading response of a resonance sensor for discriminating prostate cancer tissue from normal tissue. Indentation measurements were done on prostate tissue specimens ex vivo from 10 patients from radical prostatectomy. The measurement areas were analysed using standard histological methods. The stiffness parameter was linearly dependent on the loading force (average R2 = 0.90) and an increased loading force caused a greater stiffness contrast of prostate cancer vs normal tissue. The accuracy of the stiffness contrast was assessed by the ROC curve with the area under the curve being 0.941 for a loading force of 12.8 mN. The results are promising for the development of a resonance sensor instrument for detecting prostate cancer.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
Keyword
- Indentation
- loading
- prostate cancer
- resonance sensor
- stiffness
Publication and Content Type
- ref (subject category)
- art (subject category)
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