Improving signal detection in emission optical projection tomography via single source multi-exposure image fusion

Cheddad, AbbasUmeå universitet,Umeå centrum för molekylär medicin (UCMM) (author)

We demonstrate a technique to improve structural data obtained from Optical Projection Tomography (OPT) using Image Fusion (IF) and contrast normalization. This enables the visualization of molecular expression patterns in biological specimens with highly variable contrast values. In the approach, termed IF-OPT, different exposures are fused by assigning weighted contrasts to each. When applied to projection images from mouse organs and digital phantoms our results demonstrate the capability of IF-OPT to reveal high and low signal intensity details in challenging specimens. We further provide measurements to highlight the benefits of the new algorithm in comparison to other similar methods.

Nord, ChristofferUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)chsv0004 (author)
Hörnblad, AndreasUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)anshod02 (author)
Prunskaite-Hyyryläinen, RenataOulu Center for Cell-Matrix Research, Biocenter Oulu, Laboratory of Developmental Biology and Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, University of Oulu, Finland (author)
Eriksson, MariaUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)maer0057 (author)
Georgsson, Fredrik,1971-Umeå universitet,Institutionen för datavetenskap(Swepub:umu)frge0001 (author)
Vainio, SeppoOulu Center for Cell-Matrix Research, Biocenter Oulu, Laboratory of Developmental Biology and Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, University of Oulu, Finland (author)
Ahlgren, UlfUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)ulah0001 (author)
Umeå universitetUmeå centrum för molekylär medicin (UCMM) (creator_code:org_t)

By the author/editor: Cheddad, Abbas; Nord, Christoffe ...; Hörnblad, Andrea ...; Prunskaite-Hyyry ...; Eriksson, Maria; Georgsson, Fredr ...; show more...; Vainio, Seppo; Ahlgren, Ulf; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Other Medical Bi ...

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