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A structural equati...
A structural equation modelling approach to explore the role of B vitamins and immune markers in lung cancer risk
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Baltar, Valéria Troncoso (author)
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Xun, Wei W (author)
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- Johansson, Mattias (author)
- International Agency for Research on Cancer, Lyon, France
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Ferrari, Pietro (author)
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Chuang, Shu-Chun (author)
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Relton, Caroline (author)
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Ueland, Per Magne (author)
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Midttun, Oivind (author)
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Slimani, Nadia (author)
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Jenab, Mazda (author)
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Clavel-Chapelon, Françoise (author)
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Boutron-Ruault, Marie-Christine (author)
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Fagherazzi, Guy (author)
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Kaaks, Rudolf (author)
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Rohrmann, Sabine (author)
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Boeing, Heiner (author)
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Weikert, Cornelia (author)
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Bueno-de-Mesquita, Bas (author)
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Boshuizen, Hendriek (author)
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van Gils, Carla H (author)
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Onland-Moret, N Charlotte (author)
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Agudo, Antonio (author)
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Barricarte, Aurelio (author)
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Navarro, Carmen (author)
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Rodríguez, Laudina (author)
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Castaño, José Maria Huerta (author)
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Larrañaga, Nerea (author)
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Allen, Naomi E (author)
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Crowe, Francesca (author)
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Gallo, Valentina (author)
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Norat, Teresa (author)
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Krogh, Vittorio (author)
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Masala, Giovanna (author)
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Panico, Salvatore (author)
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Sacerdote, Carlotta (author)
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Tumino, Rosario (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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- Rasmuson, Torgny (author)
- Umeå universitet,Onkologi
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- Hallmans, Göran (author)
- Umeå universitet,Enheten för biobanksforskning,Näringsforskning
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Roswall, Nina (author)
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Tjønneland, Anne (author)
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Riboli, Elio (author)
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Brennan, Paul (author)
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Vineis, Paolo (author)
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(creator_code:org_t)
- 2013-03-27
- 2013
- English.
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In: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 28:8, s. 677-688
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The one-carbon metabolism (OCM) is considered key in maintaining DNA integrity and regulating gene expression, and may be involved in the process of carcinogenesis. Several B-vitamins and amino acids have been implicated in lung cancer risk, via the OCM directly as well as immune system activation. However it is unclear whether these factors act independently or through complex mechanisms. The current study applies structural equations modelling (SEM) to further disentangle the mechanisms involved in lung carcinogenesis. SEM allows simultaneous estimation of linear relations where a variable can be the outcome in one equation and the predictor in another, as well as allowing estimation using latent variables (factors estimated by correlation matrix). A large number of biomarkers have been analysed from 891 lung cancer cases and 1,747 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Four putative mechanisms in the OCM and immunity were investigated in relation to lung cancer risk: methionine-homocysteine metabolism, folate cycle, transsulfuration, and mechanisms involved in inflammation and immune activation, all adjusted for tobacco exposure. The hypothesized SEM model confirmed a direct and protective effect for factors representing methionine-homocysteine metabolism (p = 0.020) and immune activation (p = 0.021), and an indirect protective effect of folate cycle (p = 0.019), after adjustment for tobacco smoking. In conclusion, our results show that in the investigation of the involvement of the OCM, the folate cycle and immune system in lung carcinogenesis, it is important to consider complex pathways (by applying SEM) rather than the effects of single vitamins or nutrients (e.g. using traditional multiple regression). In our study SEM were able to suggest a greater role of the methionine-homocysteine metabolism and immune activation over other potential mechanisms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- B vitamins
- folate
- methionine
- lung cancer
- immune markers
- structural equation model
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Baltar, Valéria ...
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Xun, Wei W
-
Johansson, Matti ...
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Ferrari, Pietro
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Chuang, Shu-Chun
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Relton, Caroline
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show more...
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Ueland, Per Magn ...
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Midttun, Oivind
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Slimani, Nadia
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Jenab, Mazda
-
Clavel-Chapelon, ...
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Boutron-Ruault, ...
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Fagherazzi, Guy
-
Kaaks, Rudolf
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Rohrmann, Sabine
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Boeing, Heiner
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Weikert, Corneli ...
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Bueno-de-Mesquit ...
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Boshuizen, Hendr ...
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van Gils, Carla ...
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Onland-Moret, N ...
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Agudo, Antonio
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Barricarte, Aure ...
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Navarro, Carmen
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Rodríguez, Laudi ...
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Castaño, José Ma ...
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Larrañaga, Nerea
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Khaw, Kay-Tee
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Wareham, Nick
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Allen, Naomi E
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Crowe, Francesca
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Gallo, Valentina
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Norat, Teresa
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Krogh, Vittorio
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Masala, Giovanna
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Panico, Salvator ...
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Sacerdote, Carlo ...
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Tumino, Rosario
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Trichopoulou, An ...
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Lagiou, Pagona
-
Trichopoulos, Di ...
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Rasmuson, Torgny
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Hallmans, Göran
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Roswall, Nina
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Tjønneland, Anne
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Riboli, Elio
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Brennan, Paul
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Vineis, Paolo
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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European Journal ...
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Umeå University